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- Antigen structure
- References [58]
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- Product number
- 12-9966-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Gata-3 Monoclonal Antibody (TWAJ), PE, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody TWAJ recognizes mouse and human Gata-3, a member of the Gata family of transcription factors. Gata-3 is a T cell-specific transcription factor important for thymic development and Th2 differentiation. Expression during embryonic development is found in the central nervous system, skin, mammary glands and kidney. During development, the expression of Gata-3 is essential as homozygous knock-out of Gata-3 is embryonic lethal. The Gata-3 is also essential for T cell commitment and survival. In the thymus, expression is found mainly on the CD4 single positive cells. During Th2 differentiation, Gata-3 binds to the IL-4 promoter as well as represses the expression of T-bet, thus inhibiting Th1 differentiation.
- Conjugate
- Yellow dye
- Antibody clone number
- TWAJ
- Concentration
- 5 µL/Test
Submitted references Candida tropicalis Infection Modulates the Gut Microbiome and Confers Enhanced Susceptibility to Colitis in Mice.
Eosinophils, but Not Type 2 Innate Lymphoid Cells, Are the Predominant Source of Interleukin 4 during the Innate Phase of Leishmania major Infection.
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
Lymph node-resident dendritic cells drive T(H)2 cell development involving MARCH1.
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.
Type 2 Innate Lymphoid Cells Accumulate in the Brain After Hypoxia-Ischemia but Do Not Contribute to the Development of Preterm Brain Injury.
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103(+)CD11b(+) Dendritic Cells.
Sex-specific adipose tissue imprinting of regulatory T cells.
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors.
Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses.
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.
TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity.
The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma.
Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases.
CD4(+) T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.
Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity.
β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells.
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity.
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4(+) Th2 responses and promote chronic infection.
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung.
Treatment with cyclophosphamide supported by various dendritic cell-based vaccines induces diversification in CD4⁺ T cell response against MC38 colon carcinoma.
Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.
Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma.
Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses.
Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development.
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy.
Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.
T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils.
MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung.
Phenotypic Identification of Spinal Cord-Infiltrating CD4(+) T Lymphocytes in a Murine Model of Neuropathic Pain.
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.
Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for Sézary syndrome.
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.
STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria.
IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures.
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
IL-33 induces IL-9 production in human CD4+ T cells and basophils.
Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells.
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Role of CD44 in the differentiation of Th1 and Th2 cells: CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin.
Normalization of obesity-associated insulin resistance through immunotherapy.
Di Martino L, De Salvo C, Buela KA, Hager C, Ghannoum M, Osme A, Buttò L, Bamias G, Pizarro TT, Cominelli F
Cellular and molecular gastroenterology and hepatology 2022;13(3):901-923
Cellular and molecular gastroenterology and hepatology 2022;13(3):901-923
Eosinophils, but Not Type 2 Innate Lymphoid Cells, Are the Predominant Source of Interleukin 4 during the Innate Phase of Leishmania major Infection.
Sasse C, Barinberg D, Obermeyer S, Debus A, Schleicher U, Bogdan C
Pathogens (Basel, Switzerland) 2022 Jul 25;11(8)
Pathogens (Basel, Switzerland) 2022 Jul 25;11(8)
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
Krzywinska E, Sobecki M, Nagarajan S, Zacharjasz J, Tambuwala MM, Pelletier A, Cummins E, Gotthardt D, Fandrey J, Kerdiles YM, Peyssonnaux C, Taylor CT, Sexl V, Stockmann C
The Journal of experimental medicine 2022 Feb 7;219(2)
The Journal of experimental medicine 2022 Feb 7;219(2)
Lymph node-resident dendritic cells drive T(H)2 cell development involving MARCH1.
Castellanos CA, Ren X, Gonzalez SL, Li HK, Schroeder AW, Liang HE, Laidlaw BJ, Hu D, Mak ACY, Eng C, Rodríguez-Santana JR, LeNoir M, Yan Q, Celedón JC, Burchard EG, Zamvil SS, Ishido S, Locksley RM, Cyster JG, Huang X, Shin JS
Science immunology 2021 Oct 15;6(64):eabh0707
Science immunology 2021 Oct 15;6(64):eabh0707
Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice.
Kuhn JA, Vainchtein ID, Braz J, Hamel K, Bernstein M, Craik V, Dahlgren MW, Ortiz-Carpena J, Molofsky AB, Molofsky AV, Basbaum AI
eLife 2021 Oct 15;10
eLife 2021 Oct 15;10
Type 2 Innate Lymphoid Cells Accumulate in the Brain After Hypoxia-Ischemia but Do Not Contribute to the Development of Preterm Brain Injury.
Zelco A, Rocha-Ferreira E, Nazmi A, Ardalan M, Chumak T, Nilsson G, Hagberg H, Mallard C, Wang X
Frontiers in cellular neuroscience 2020;14:249
Frontiers in cellular neuroscience 2020;14:249
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103(+)CD11b(+) Dendritic Cells.
Ko HJ, Hong SW, Verma R, Jung J, Lee M, Kim N, Kim D, Surh CD, Kim KS, Rudra D, Im SH
Frontiers in immunology 2020;11:1897
Frontiers in immunology 2020;11:1897
Sex-specific adipose tissue imprinting of regulatory T cells.
Vasanthakumar A, Chisanga D, Blume J, Gloury R, Britt K, Henstridge DC, Zhan Y, Torres SV, Liene S, Collins N, Cao E, Sidwell T, Li C, Spallanzani RG, Liao Y, Beavis PA, Gebhardt T, Trevaskis N, Nutt SL, Zajac JD, Davey RA, Febbraio MA, Mathis D, Shi W, Kallies A
Nature 2020 Mar;579(7800):581-585
Nature 2020 Mar;579(7800):581-585
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Sidwell T, Liao Y, Garnham AL, Vasanthakumar A, Gloury R, Blume J, Teh PP, Chisanga D, Thelemann C, de Labastida Rivera F, Engwerda CR, Corcoran L, Kometani K, Kurosaki T, Smyth GK, Shi W, Kallies A
Nature communications 2020 Jan 14;11(1):252
Nature communications 2020 Jan 14;11(1):252
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Shin B, Benavides GA, Geng J, Koralov SB, Hu H, Darley-Usmar VM, Harrington LE
Cell reports 2020 Feb 11;30(6):1898-1909.e4
Cell reports 2020 Feb 11;30(6):1898-1909.e4
Insulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
DiToro D, Harbour SN, Bando JK, Benavides G, Witte S, Laufer VA, Moseley C, Singer JR, Frey B, Turner H, Bruning J, Darley-Usmar V, Gao M, Conover C, Hatton RD, Frank S, Colonna M, Weaver CT
Immunity 2020 Apr 14;52(4):650-667.e10
Immunity 2020 Apr 14;52(4):650-667.e10
Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production.
Mathä L, Shim H, Steer CA, Yin YH, Martinez-Gonzalez I, Takei F
PloS one 2019;14(3):e0214286
PloS one 2019;14(3):e0214286
Compartmentalized gut lymph node drainage dictates adaptive immune responses.
Esterházy D, Canesso MCC, Mesin L, Muller PA, de Castro TBR, Lockhart A, ElJalby M, Faria AMC, Mucida D
Nature 2019 May;569(7754):126-130
Nature 2019 May;569(7754):126-130
Distinct immunocyte-promoting and adipocyte-generating stromal components coordinate adipose tissue immune and metabolic tenors.
Spallanzani RG, Zemmour D, Xiao T, Jayewickreme T, Li C, Bryce PJ, Benoist C, Mathis D
Science immunology 2019 May 3;4(35)
Science immunology 2019 May 3;4(35)
Ets1 suppresses atopic dermatitis by suppressing pathogenic T cell responses.
Lee CG, Kwon HK, Kang H, Kim Y, Nam JH, Won YH, Park S, Kim T, Kang K, Rudra D, Jun CD, Park ZY, Im SH
JCI insight 2019 Mar 7;4(5)
JCI insight 2019 Mar 7;4(5)
Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming.
Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM
Immunity 2019 Jun 18;50(6):1425-1438.e5
Immunity 2019 Jun 18;50(6):1425-1438.e5
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Scheer S, Ackloo S, Medina TS, Schapira M, Li F, Ward JA, Lewis AM, Northrop JP, Richardson PL, Kaniskan HÜ, Shen Y, Liu J, Smil D, McLeod D, Zepeda-Velazquez CA, Luo M, Jin J, Barsyte-Lovejoy D, Huber KVM, De Carvalho DD, Vedadi M, Zaph C, Brown PJ, Arrowsmith CH
Nature communications 2019 Jan 3;10(1):19
Nature communications 2019 Jan 3;10(1):19
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.
Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA
Immunity 2019 Feb 19;50(2):362-377.e6
Immunity 2019 Feb 19;50(2):362-377.e6
TNFR2 Signaling Enhances ILC2 Survival, Function, and Induction of Airway Hyperreactivity.
Hurrell BP, Galle-Treger L, Jahani PS, Howard E, Helou DG, Banie H, Soroosh P, Akbari O
Cell reports 2019 Dec 24;29(13):4509-4524.e5
Cell reports 2019 Dec 24;29(13):4509-4524.e5
The Combination Therapy of Dietary Galacto-Oligosaccharides With Budesonide Reduces Pulmonary Th2 Driving Mediators and Mast Cell Degranulation in a Murine Model of House Dust Mite Induced Asthma.
Verheijden KAT, Braber S, Leusink-Muis T, Jeurink PV, Thijssen S, Kraneveld AD, Garssen J, Folkerts G, Willemsen LEM
Frontiers in immunology 2018;9:2419
Frontiers in immunology 2018;9:2419
Effects of Anti-Integrin Treatment With Vedolizumab on Immune Pathways and Cytokines in Inflammatory Bowel Diseases.
Rath T, Billmeier U, Ferrazzi F, Vieth M, Ekici A, Neurath MF, Atreya R
Frontiers in immunology 2018;9:1700
Frontiers in immunology 2018;9:1700
CD4(+) T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development.
Cobbold SP, Adams E, Howie D, Waldmann H
Frontiers in immunology 2018;9:1381
Frontiers in immunology 2018;9:1381
Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity.
Cuadrado E, van den Biggelaar M, de Kivit S, Chen YY, Slot M, Doubal I, Meijer A, van Lier RAW, Borst J, Amsen D
Immunity 2018 May 15;48(5):1046-1059.e6
Immunity 2018 May 15;48(5):1046-1059.e6
β-Arrestin-2-Dependent Signaling Promotes CCR4-mediated Chemotaxis of Murine T-Helper Type 2 Cells.
Lin R, Choi YH, Zidar DA, Walker JKL
American journal of respiratory cell and molecular biology 2018 Jun;58(6):745-755
American journal of respiratory cell and molecular biology 2018 Jun;58(6):745-755
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Hirota K, Hashimoto M, Ito Y, Matsuura M, Ito H, Tanaka M, Watanabe H, Kondoh G, Tanaka A, Yasuda K, Kopf M, Potocnik AJ, Stockinger B, Sakaguchi N, Sakaguchi S
Immunity 2018 Jun 19;48(6):1220-1232.e5
Immunity 2018 Jun 19;48(6):1220-1232.e5
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Li Q, Li D, Zhang X, Wan Q, Zhang W, Zheng M, Zou L, Elly C, Lee JH, Liu YC
Immunity 2018 Feb 20;48(2):258-270.e5
Immunity 2018 Feb 20;48(2):258-270.e5
Characterisation of innate lymphoid cell populations at different sites in mice with defective T cell immunity.
Dutton EE, Camelo A, Sleeman M, Herbst R, Carlesso G, Belz GT, Withers DR
Wellcome open research 2017;2:117
Wellcome open research 2017;2:117
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control.
Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, McKenzie ANJ, Fallon PG
The Journal of experimental medicine 2017 Sep 4;214(9):2507-2521
The Journal of experimental medicine 2017 Sep 4;214(9):2507-2521
IRF-8 regulates expansion of myeloid-derived suppressor cells and Foxp3+ regulatory T cells and modulates Th2 immune responses to gastrointestinal nematode infection.
Valanparambil RM, Tam M, Gros PP, Auger JP, Segura M, Gros P, Jardim A, Geary TG, Ozato K, Stevenson MM
PLoS pathogens 2017 Oct;13(10):e1006647
PLoS pathogens 2017 Oct;13(10):e1006647
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.
Floudas A, Cluxton CD, Fahel J, Khan AR, Saunders SP, Amu S, Alcami A, Fallon PG
PLoS neglected tropical diseases 2017 Oct;11(10):e0006012
PLoS neglected tropical diseases 2017 Oct;11(10):e0006012
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Levine AG, Mendoza A, Hemmers S, Moltedo B, Niec RE, Schizas M, Hoyos BE, Putintseva EV, Chaudhry A, Dikiy S, Fujisawa S, Chudakov DM, Treuting PM, Rudensky AY
Nature 2017 Jun 15;546(7658):421-425
Nature 2017 Jun 15;546(7658):421-425
Primary Heligmosomoides polygyrus bakeri infection induces myeloid-derived suppressor cells that suppress CD4(+) Th2 responses and promote chronic infection.
Valanparambil RM, Tam M, Jardim A, Geary TG, Stevenson MM
Mucosal immunology 2017 Jan;10(1):238-249
Mucosal immunology 2017 Jan;10(1):238-249
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Zamarin D, Holmgaard RB, Ricca J, Plitt T, Palese P, Sharma P, Merghoub T, Wolchok JD, Allison JP
Nature communications 2017 Feb 13;8:14340
Nature communications 2017 Feb 13;8:14340
Characterization and Quantification of Innate Lymphoid Cell Subsets in Human Lung.
De Grove KC, Provoost S, Verhamme FM, Bracke KR, Joos GF, Maes T, Brusselle GG
PloS one 2016;11(1):e0145961
PloS one 2016;11(1):e0145961
Treatment with cyclophosphamide supported by various dendritic cell-based vaccines induces diversification in CD4⁺ T cell response against MC38 colon carcinoma.
Wojas-Turek J, Szczygieł A, Kicielińska J, Rossowska J, Piasecki E, Pajtasz-Piasecka E
International journal of oncology 2016 Feb;48(2):493-505
International journal of oncology 2016 Feb;48(2):493-505
Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.
Deng YQ, Yang YQ, Wang SB, Li F, Liu MZ, Hua QQ, Tao ZZ
PloS one 2015;10(9):e0139322
PloS one 2015;10(9):e0139322
Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma.
Hadebe S, Kirstein F, Fierens K, Chen K, Drummond RA, Vautier S, Sajaniemi S, Murray G, Williams DL, Redelinghuys P, Reinhart TA, Fallert Junecko BA, Kolls JK, Lambrecht BN, Brombacher F, Brown GD
PloS one 2015;10(8):e0134219
PloS one 2015;10(8):e0134219
Triclosan Induces Thymic Stromal Lymphopoietin in Skin Promoting Th2 Allergic Responses.
Marshall NB, Lukomska E, Long CM, Kashon ML, Sharpnack DD, Nayak AP, Anderson KL, Jean Meade B, Anderson SE
Toxicological sciences : an official journal of the Society of Toxicology 2015 Sep;147(1):127-39
Toxicological sciences : an official journal of the Society of Toxicology 2015 Sep;147(1):127-39
Mesenchymal Stem Cells Reduce Murine Atherosclerosis Development.
Frodermann V, van Duijn J, van Pel M, van Santbrink PJ, Bot I, Kuiper J, de Jager SC
Scientific reports 2015 Oct 22;5:15559
Scientific reports 2015 Oct 22;5:15559
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D
Nature 2015 Mar 12;519(7542):242-6
Nature 2015 Mar 12;519(7542):242-6
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
Cousin C, Aubatin A, Le Gouvello S, Apetoh L, Castellano F, Molinier-Frenkel V
European journal of immunology 2015 Jun;45(6):1772-82
European journal of immunology 2015 Jun;45(6):1772-82
Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy.
Rasouli J, Ciric B, Imitola J, Gonnella P, Hwang D, Mahajan K, Mari ER, Safavi F, Leist TP, Zhang GX, Rostami A
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5085-93
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5085-93
Hyperreactive onchocerciasis is characterized by a combination of Th17-Th2 immune responses and reduced regulatory T cells.
Katawa G, Layland LE, Debrah AY, von Horn C, Batsa L, Kwarteng A, Arriens S, W Taylor D, Specht S, Hoerauf A, Adjobimey T
PLoS neglected tropical diseases 2015 Jan;9(1):e3414
PLoS neglected tropical diseases 2015 Jan;9(1):e3414
T cell-derived IL-4/IL-13 protects mice against fatal Schistosoma mansoni infection independently of basophils.
Schwartz C, Oeser K, Prazeres da Costa C, Layland LE, Voehringer D
Journal of immunology (Baltimore, Md. : 1950) 2014 Oct 1;193(7):3590-9
Journal of immunology (Baltimore, Md. : 1950) 2014 Oct 1;193(7):3590-9
MicroRNA-155 is essential for T(H)2-mediated allergen-induced eosinophilic inflammation in the lung.
Malmhäll C, Alawieh S, Lu Y, Sjöstrand M, Bossios A, Eldh M, Rådinger M
The Journal of allergy and clinical immunology 2014 May;133(5):1429-38, 1438.e1-7
The Journal of allergy and clinical immunology 2014 May;133(5):1429-38, 1438.e1-7
Phenotypic Identification of Spinal Cord-Infiltrating CD4(+) T Lymphocytes in a Murine Model of Neuropathic Pain.
Draleau K, Maddula S, Slaiby A, Nutile-McMenemy N, De Leo J, Cao L
Journal of pain & relief 2014 Jun;Suppl 3:003
Journal of pain & relief 2014 Jun;Suppl 3:003
Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease.
Munneke JM, Björklund AT, Mjösberg JM, Garming-Legert K, Bernink JH, Blom B, Huisman C, van Oers MH, Spits H, Malmberg KJ, Hazenberg MD
Blood 2014 Jul 31;124(5):812-21
Blood 2014 Jul 31;124(5):812-21
Impaired proteasome function activates GATA3 in T cells and upregulates CTLA-4: relevance for Sézary syndrome.
Gibson HM, Mishra A, Chan DV, Hake TS, Porcu P, Wong HK
The Journal of investigative dermatology 2013 Jan;133(1):249-57
The Journal of investigative dermatology 2013 Jan;133(1):249-57
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells.
Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, te Velde AA, Fokkens WJ, van Drunen CM, Spits H
Immunity 2012 Oct 19;37(4):649-59
Immunity 2012 Oct 19;37(4):649-59
STAT6 regulates natural helper cell proliferation during lung inflammation initiated by Alternaria.
Doherty TA, Khorram N, Chang JE, Kim HK, Rosenthal P, Croft M, Broide DH
American journal of physiology. Lung cellular and molecular physiology 2012 Oct 1;303(7):L577-88
American journal of physiology. Lung cellular and molecular physiology 2012 Oct 1;303(7):L577-88
IL-1 family members IL-18 and IL-33 upregulate the inflammatory potential of differentiated human Th1 and Th2 cultures.
Blom L, Poulsen LK
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 1;189(9):4331-7
Journal of immunology (Baltimore, Md. : 1950) 2012 Nov 1;189(9):4331-7
CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.
Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 15;188(4):2001-13
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 15;188(4):2001-13
IL-33 induces IL-9 production in human CD4+ T cells and basophils.
Blom L, Poulsen BC, Jensen BM, Hansen A, Poulsen LK
PloS one 2011;6(7):e21695
PloS one 2011;6(7):e21695
Requirement of GATA-binding protein 3 for II13 gene expression in IL-18-stimulated Th1 cells.
Nakahira M, Nakanishi K
International immunology 2011 Dec;23(12):761-72
International immunology 2011 Dec;23(12):761-72
Th-1 lymphocytes induce dendritic cell tumor killing activity by an IFN-γ-dependent mechanism.
LaCasse CJ, Janikashvili N, Larmonier CB, Alizadeh D, Hanke N, Kartchner J, Situ E, Centuori S, Har-Noy M, Bonnotte B, Katsanis E, Larmonier N
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6310-7
Journal of immunology (Baltimore, Md. : 1950) 2011 Dec 15;187(12):6310-7
FOXP3+ regulatory T cells and T helper 1, T helper 2, and T helper 17 cells in human early pregnancy decidua.
Mjösberg J, Berg G, Jenmalm MC, Ernerudh J
Biology of reproduction 2010 Apr;82(4):698-705
Biology of reproduction 2010 Apr;82(4):698-705
Role of CD44 in the differentiation of Th1 and Th2 cells: CD44-deficiency enhances the development of Th2 effectors in response to sheep RBC and chicken ovalbumin.
Guan H, Nagarkatti PS, Nagarkatti M
Journal of immunology (Baltimore, Md. : 1950) 2009 Jul 1;183(1):172-80
Journal of immunology (Baltimore, Md. : 1950) 2009 Jul 1;183(1):172-80
Normalization of obesity-associated insulin resistance through immunotherapy.
Winer S, Chan Y, Paltser G, Truong D, Tsui H, Bahrami J, Dorfman R, Wang Y, Zielenski J, Mastronardi F, Maezawa Y, Drucker DJ, Engleman E, Winer D, Dosch HM
Nature medicine 2009 Aug;15(8):921-9
Nature medicine 2009 Aug;15(8):921-9
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- Staining of CD4 (Product # 11-0041-82) single positive (left) and CD8 (Product # 45-0081-82) single positive (right) BALB/c thymocytes using the Foxp3 Staining Buffer Set (Product # 00-5523-00) with Rat IgG2b K Isotype Control PE (Product # 12-4031-82) (blue histogram) or Anti-Human/Mouse Gata-3 PE (purple histogram).
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- Fig 5 Lentiviral-mmu-miR-135a treatment influences Th cell polarization. The expression of T-bet and GATA-3 protein in CD4 + T cells was measured in the spleens of normal (control), AR (AR-induced), positive (AR-induced, treated with lentiviral-mmu-miR-135a), and negative (AR-induced, treated with empty lentivirus) mice using flow cytometry. (A) Representative dot plots from each experimental group. The percentages of CD4 + T-bet + T cells (B) and CD4 + GATA-3 + T cells (C) were also calculated. Data are presented as the mean +- SEM. *P
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- Extended Data Figure 7 Distinguishing the drivers of autoimmunity in the absence of T-bet + Treg cells a,b , ex-Treg cells are no more pathogenic than effector CD4 T cells. a , CD4 + CD25 + (Treg) cells were sorted from lymph nodes of Tbx21 RFP-Cre Foxp3 WT mice, and CD4 + CD25 - (effector) and CD4 + CD25 lo (exTreg) cells were sorted from lymph nodes of Tbx21 RFP-Cre Foxp3 FL mice for transfer into Tcrb - / - Tcrd - / - mice. Intracellular staining for Foxp3 demonstrates purity of cell populations. b , Weights of Tcrb - / - Tcrd - / - mice receiving CD4 + CD25 + (white squares), CD4 + CD25 - (black squares), and CD4 + CD25 lo (gray squares) cells. c , Percentages and numbers of the indicated T cell populations in spleens of mice analyzed on d62 post transfer. d,e , T-bet + effector alphabetaT cells drive disease upon ablation of T-bet + Treg cells. Lethally irradiated Tcrb - / - Tcrd - / - mice were reconstituted with a 1:1 mix of CD45.2 + Tbx21 RFP-Cre/WT R26 iDTR T-cell depleted bone marrow cells with either CD45.1 + Foxp3 KO , CD45.1 + Foxp3 WT , or CD45.2 + Tcrb KO T-cell depleted bone marrow cells. Mice were injected with 0.5mug diphtheria toxin (DT) on day 0, then treated daily with 0.1mug DT for 22 days before analysis. d , Weight loss in Tbx21 RFP-Cre/WT R26 iDTR :Foxp3 KO (red line) vs. Tbx21 RFP-Cre/WT R26 iDTR :Foxp3 WT (black line) vs. Tbx21 RFP-Cre/WT R26 iDTR :Tcrb KO (blue line) reconstituted mice. e , Representative fl
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