Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- ABIN359763 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Cullin 4A (CUL4A) (N-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human CUL4a.
- Description
- Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- N-Term
- Vial size
- 0.4 mL
- Concentration
- 0.25 mg/mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation.
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
Huang J, Chen J
Oncogene 2008 Jul 3;27(29):4056-64
Oncogene 2008 Jul 3;27(29):4056-64
WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.
Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, Xiong Y
Genes & development 2008 Apr 1;22(7):866-71
Genes & development 2008 Apr 1;22(7):866-71
The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor.
Wen X, Duus KM, Friedrich TD, de Noronha CM
The Journal of biological chemistry 2007 Sep 14;282(37):27046-57
The Journal of biological chemistry 2007 Sep 14;282(37):27046-57
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- Western blot analysis of CUL4a (arrow) using rabbit polyclonal CUL4a Antibody