NBP2-47797PCP

antibody from Novus Biologicals

Targeting: ESR2 ER-beta, Erb, NR3A2

Western blot (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-47797PCP

Provider

Novus Biologicals

Product name

Mouse Monoclonal ER beta/NR3A2 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark.