Explore
Validate
Learn
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 17-2589-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD258 (LIGHT) Monoclonal Antibody (7-3 (7)), APC, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This 7-3 (7) monoclonal antibody reacts with human CD258 (also known as LIGHT), a 29-kDa type II transmembrane protein that is a member of the TNF ligand superfamily related to lymphotoxin-β (LT-β). Expressed on activated T cells, particularly CD8+ T cells, LIGHT plays a role in cell survival, inflammation, and tumor eradication. Furthermore, upon binding its ligand, herpesvirus entry mediator (HVEM), LIGHT induces a costimulatory effect on T cells, enhancing T cell proliferation and cytokine production. LIGHT has also been shown to indirectly interact with the LT-β receptor.
- Antibody clone number
- 7-3 (7)
- Concentration
- 5 µL/Test
Submitted references LIGHT expression by mucosal T cells may regulate IFN-gamma expression in the intestine.
Cohavy O, Zhou J, Granger SW, Ware CF, Targan SR
Journal of immunology (Baltimore, Md. : 1950) 2004 Jul 1;173(1):251-8
Journal of immunology (Baltimore, Md. : 1950) 2004 Jul 1;173(1):251-8
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of PMA/Ionomycin-stimulated normal human peripheral blood cells with Anti-Human CD8a PE (Product # 12-0088-80) and Mouse IgG1 kappa Isotype Control APC (Product # 17-4714-81) (left) or Anti-Human CD258 (LIGHT) APC (right). Total viable cells were used for analysis.
