10-7544

antibody from ABEOMICS Inc.

Targeting: GCSAM GCET2, HGAL, MGC40441

Antibody data

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Validation data

Product number: 10-7544 - Provider product page
Provider: ABEOMICS Inc.
Product name: Anti-HGAL Antibody
Antibody type: Monoclonal
Description: Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM). HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1). HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Antigen sequence: A full length human HGAL protein wa s used as the immunogen for this an tibody
Isotype: IgG
Antibody clone number: ABM43E6
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing

GCSAM protein structure - 10-7544 shown in red.