66470-2-Ig

antibody from Proteintech Group

Targeting: CASP3 apopain, CPP32, CPP32B, Yama

Provider product page for 66470-2-Ig

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Product number: 66470-2-Ig - Provider product page
Provider: Proteintech Group
Product name: Caspase 3/p17/p19 antibody
Antibody type: Monoclonal
Description: KD/KO validated Caspase 3/p17/p19 antibody (Cat. #66470-2-Ig) is a mouse monoclonal antibody that shows reactivity with Human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2G4B2
Vial size: 20ul, 150ul

CASP3 protein structure - 66470-2-Ig shown in red.

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Du X, Li C, Zhang S, Sun C, Zhang X, Chen C, Wang X, Cheng F, Wang Q
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Tea Polyphenols Prevent Sepsis-Induced Lung Injury via Promoting Translocation of DJ-1 to Mitochondria.

Jia CM, Zhang FW, Wang SJ, Wang W, Li Y
Frontiers in cell and developmental biology 2021;9:622507

Hydroxysafflor yellow A acutely attenuates blood-brain barrier permeability, oxidative stress, inflammation and apoptosis in traumatic brain injury in rats1.

Xu J, Zhan T, Zheng W, Huang YK, Chen K, Zhang XH, Ren P, Huang X
Acta cirurgica brasileira 2021;35(12):e351202

Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study.

Zhang P, Yu B, Jin X, Zhao T, Ye F, Liu X, Li P, Zheng X, Chen W, Li Q
International journal of nanomedicine 2021;16:4661-4674

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway.

Zheng B, Yang Y, Li J, Li J, Zuo S, Chu X, Xu S, Ma D, Chu L
Drug design, development and therapy 2021;15:543-556

Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.

Peng HH, Wang JN, Xiao LF, Yan M, Chen SP, Wang L, Yang K
Frontiers in genetics 2021;12:651647

Salubrinal Exposes Anticancer Properties in Inflammatory Breast Cancer Cells by Manipulating the Endoplasmic Reticulum Stress Pathway.

Alsterda A, Asha K, Powrozek O, Repak M, Goswami S, Dunn AM, Memmel HC, Sharma-Walia N
Frontiers in oncology 2021;11:654940

Koumiss promotes Mycobacterium bovis infection by disturbing intestinal flora and inhibiting endoplasmic reticulum stress.

Wang H, Hussain T, Yao J, Li J, Sabir N, Liao Y, Liang Z, Wang Y, Liu Y, Zhao D, Zhou X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21777

Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.

Ma S, Zhou J, Huang T, Zhang Z, Xing Q, Zhou X, Zhang K, Yao M, Cheng T, Wang X, Wen X, Guan F
Acta biomaterialia 2021 Sep 1;131:185-197

[8]-Gingerol exerts anti-myocardial ischemic effects in rats via modulation of the MAPK signaling pathway and L-type Ca²⁺ channels.

Xue Y, Zhang M, Zheng B, Zhang Y, Chu X, Liu Y, Li Z, Han X, Chu L
Pharmacology research & perspectives 2021 Oct;9(5):e00852

Establishment and Evaluation of a Novel High-Efficiency Model of Graded Traumatic Brain Injury in Mice.

Chen B, Shi QX, Nie C, Zhao ZP, Luo L, Zhao QJ, Si SY, Xu BX, Wang T, Gao LY, Gu JW
World neurosurgery 2021 Oct;154:e7-e18

Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.

Zeng L, Zou Q, Huang P, Xiong L, Cheng Y, Chen Q, Li Y, He H, Yi W, Wei W
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Fan X, Fu H, Xie N, Guo H, Fu T, Shan Y
Aging 2021 Oct 8;13(19):22830-22842

ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.

Li R, Hao Y, Wang Q, Meng Y, Wu K, Liu C, Xu L, Liu Z, Zhao L
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Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.

Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558

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Photodiagnosis and photodynamic therapy 2021 Oct 17;:102591

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Shen HY, Li XQ, Fan WQ, Wang YW, Huang F, Wu JQ, Zhang W, Feng XS, Chao X
European journal of pharmacology 2021 Oct 15;909:174405

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Hu Z, Xu H, Lu Y, He Q, Yan C, Zhao X, Tian Y, Yang C, Zhang Z, Qiu M, Wang Y
Experimental cell research 2021 Oct 15;407(2):112833

Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.

Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653

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Dai W, He QZ, Zhu BQ, Zeng HC
Journal of applied toxicology : JAT 2021 Nov;41(11):1839-1851

Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.

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Phytotherapy research : PTR 2021 Nov 30;

USP39 attenuates the antitumor activity of cisplatin on colon cancer cells dependent on p53.

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Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.

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Liu M, Zheng B, Liu P, Zhang J, Chu X, Dong C, Shi J, Liang Y, Chu L, Liu Y, Han X
Molecular medicine reports 2021 Jun;23(6)

Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.

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Prognostic signature composed of transcription factors accurately predicts the prognosis of gastric cancer patients.

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Sun S, Jin Y, Yang J, Zhao Z, Rao Q
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Shu J, Gu Y, Jin L, Wang H
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Zheng J, Zhu X, He Y, Hou S, Liu T, Zhi K, Hou T, Gao L
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70

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Journal of medicinal chemistry 2021 Dec 23;64(24):17920-17935

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Shan M, Zhang X, Fang X, Tian J, Song L, Chen Y, Qiu Z, Zhu D, Luo H, Wang Z
International journal of biological macromolecules 2021 Dec 15;193(Pt A):778-788

Carnosol alleviates nonalcoholic fatty liver disease by inhibiting mitochondrial dysfunction and apoptosis through targeting of PRDX3.

Geng Y, Wang Y, Sun R, Kang X, Zhao H, Zhu M, Sun Y, Hu Y, Wang Z, Tian X, Zhao Y, Yao J
Toxicology and applied pharmacology 2021 Dec 1;432:115758

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Experimental dermatology 2021 Aug;30(8):1090-1098

Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.

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Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.

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Chen Y, Liang J, Liang X, Chen J, Wang Y, Cao J, Sun C, Ye J, Chen Q
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Zhao X, Fu J, Tang W, Yu L, Xu W
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American journal of translational research 2020;12(7):3688-3701

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Li W, Goshima Y, Ohshima T
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Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability.

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Biomaterials 2020 Oct;255:120156

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Cell reports 2020 May 12;31(6):107630

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Annals of translational medicine 2020 Mar;8(6):366

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Andrology 2020 Mar;8(2):497-508

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Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, Quan C, Yao Y, Zheng Z
BMC cancer 2020 Jul 16;20(1):665

2-Methylquinazoline derivative 23BB as a highly selective histone deacetylase 6 inhibitor alleviated cisplatin-induced acute kidney injury.

Hao Y, Guo F, Huang Z, Feng Y, Xia Z, Liu J, Li L, Huang R, Lin L, Ma L, Fu P
Bioscience reports 2020 Jan 31;40(1)

A Splice Variant of NCOR2, BQ323636.1, Confers Chemoresistance in Breast Cancer by Altering the Activity of NRF2.

Leung MH, Tsoi H, Gong C, Man EP, Zona S, Yao S, Lam EW, Khoo US
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Fengbaisan suppresses endoplasmic reticulum stress by up-regulating SIRT1 expression to protect rats with chronic obstructive pulmonary diseases.

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Pharmaceutical biology 2020 Dec;58(1):878-885

Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.

Zhao Y, Lin Z, Lin Z, Zhou C, Liu G, Lin J, Zhang D, Lin D
Animals : an open access journal from MDPI 2020 Dec 27;11(1)

Curcuma oil ameliorates benign prostatic hyperplasia through suppression of the nuclear factor-kappa B signaling pathway in rats.

Wang S, Li Y, Li W, Zhang K, Yuan Z, Cai Y, Xu K, Zhou J, Du Z
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Bai X, Wang Y, Hu B, Cao Q, Xing M, Song S, Ji A
Marine drugs 2020 Apr 20;18(4)

Activation of PGC-1α and Mitochondrial Biogenesis Protects Against Prenatal Hypoxic-ischemic Brain Injury.

Jia L, Wang J, Cao H, Zhang X, Rong W, Xu Z
Neuroscience 2020 Apr 15;432:63-72

[JNK/c-Jun signaling pathway mediates arginine vasopressin neuron regeneration by promoting cytoskeleton reconstruction in rats with electrical lesions of the pituitary stalk].

Li K, Feng Z, Ou Y, Zhou M, Peng J, Gong H, Wu G, Liu Y, Qi S
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Sep 30;39(9):1099-1106

Melatonin protects circulatory death heart from ischemia/reperfusion injury via the JAK2/STAT3 signalling pathway.

Lan H, Su Y, Liu Y, Deng C, Wang J, Chen T, Jules KED, Masau JF, Li H, Wei X
Life sciences 2019 Jul 1;228:35-46

MiR-15b is a key regulator of proliferation and apoptosis of chondrocytes from patients with condylar hyperplasia by targeting IGF1, IGF1R and BCL2.

Cao P, Feng Y, Deng M, Li J, Cai H, Meng Q, Fang W, Li Y, Ke J, Long X
Osteoarthritis and cartilage 2019 Feb;27(2):336-346

Silencing TTK expression inhibits the proliferation and progression of prostate cancer.

Chen S, Wang J, Wang L, Peng H, Xiao L, Li C, Lin D, Yang K
Experimental cell research 2019 Dec 1;385(1):111669

Extracellular RNAs-TLR3 signaling contributes to cognitive decline in a mouse model of postoperative cognitive dysfunction.

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Brain, behavior, and immunity 2019 Aug;80:439-451

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UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.

Shi X, Yang L, Xie J, Zhao Y, Cong J, Li Z, Li H, Cheng X, Fan J
Molecular medicine reports 2018 Sep;18(3):3382-3388

Knockdown of LncRNA MALAT1 contributes to cell apoptosis via regulating NF-κB/CD80 axis in neonatal respiratory distress syndrome.

Juan C, Wang Q, Mao Y, Cao Q, Li S, Qiao C, Zhang D, Zhou G
The international journal of biochemistry & cell biology 2018 Nov;104:138-148

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Zou J, Zhang Y, Sun J, Wang X, Tu H, Geng S, Liu R, Chen Y, Bi Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(5):1812-1821

Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.

Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, He K
International immunopharmacology 2017 Nov;52:168-175

Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.

Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378

Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.

Liu M, Liu S, Tan W, Tang F, Long J, Li Z, Liang B, Chu C, Yang J
Molecular medicine reports 2017 Dec;16(6):8953-8963

Selective CDK7 inhibition with BS-181 suppresses cell proliferation and induces cell cycle arrest and apoptosis in gastric cancer.

Wang BY, Liu QY, Cao J, Chen JW, Liu ZS
Drug design, development and therapy 2016;10:1181-9

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