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ImmunocytochemistryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Immunocytochemistry [1]
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- Product number
- 53-9898-80 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Cytokeratin 19 Monoclonal Antibody (BA17), Alexa Fluor™ 488, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: This BA17 monoclonal antibody reacts with human cytokeratin 19 (CK19), a 44-kDa type I (acidic) intermediate filament protein that lacks the non-alpha-helical tail domain present in other keratins. Cytokeratins form the intracellular cytoskeletal network that maintains the integrity and stability of cells and tissues. Cytokeratin 19 is expressed in a wide variety of simple and stratified epithelial tissue. Moreover, cytokeratin 19 expression can be induced by vitamin A, SV40 transformation, and cancer. A soluble form of cytokeratin 19 generated by caspase 3 cleavage has also been found to be secreted by cancer cells, thus possibly indicating tumor metastasis. Cytokeratin 19 often exists as a heterodimer with cytokeratin 7, a type II keratin.
- Conjugate
- Green dye
- Antibody clone number
- BA17
- Concentration
- 0.5 mg/mL
Submitted references Isolation of circulating tumor cells and detection of EGFR mutations in patients with non-small-cell lung cancer.
Zhang Q, Nong J, Wang J, Yan Z, Yi L, Gao X, Liu Z, Zhang H, Zhang S
Oncology letters 2019 Apr;17(4):3799-3807
Oncology letters 2019 Apr;17(4):3799-3807
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunocytochemistry of fixed MCF7 cells using 10 µg/mL Mouse IgG1 K Isotype Control Alexa Fluor® 488 (left) or 10 µg/mL Anti-Human Cytokeratin 19 Alexa Fluor® 488 (right). Nuclei are stained with DAPI.
- Conjugate
- Green dye
