NBP2-34705JF646

antibody from Novus Biologicals
Targeting: PAX6 AN, AN1, AN2, D11S812E, WAGR
Provider product page for NBP2-34705JF646
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
NBP2-34705JF646 - Provider product page
Provider
Novus Biologicals
Product name
Mouse Monoclonal Pax6 Antibody
Antibody type
Monoclonal
Description
Protein A purified. Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.
Reactivity
Human, Mouse, Rat, Chicken/Avian
Host
Mouse
Isotype
IgG
Vial size
0.1 ml
Storage
Store at 4C in the dark.
PAX6 protein structure - NBP2-34705JF646 shown in red.