53-9893-80

antibody from Invitrogen Antibodies
Targeting: MUC1 ADMCKD, ADMCKD1, CD227, MCD, MCKD, MCKD1, PEM, PUM
Provider product page for 53-9893-80

Antibody data

Product number
53-9893-80 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD227 (Mucin 1) Monoclonal Antibody (SM3), Alexa Fluor™ 488, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This SM3 monoclonal antibody reacts with the under-glycosylated form of human Mucin 1 (MUC1, CD227), a large glycoprotein belonging to the mucin protein family. Mucin 1 contains a polypeptide core consisting of multiple tandem repeats that become highly glycosylated. Mucin 1 is typically expressed in ductal or glandular epithelial cells and is localized to the apical membrane. In cancerous cells, Mucin 1 expression is increased and membrane-specific localization is lost resulting in expression throughout the membrane and cytoplasm. High levels of under-glycosylated Mucin 1 are thought to affect cell behavior during both invasion and metastasis as well as in immune recognition. In addition, under-glycosylated Mucin 1 is shed from the epithelial cell surface and can be detected in circulation. Alterations in Mucin 1 glycosylation are found in most adenocarcinomas of the breast, lung, pancreas, prostate, and ovary. Mucin 1 has recently been shown to co-localize and interact with members of the erbB receptor kinase family, proteins that are upregulated in more aggressive forms of breast cancer.
Conjugate
Green dye
Antibody clone number
SM3
Concentration
0.5 mg/mL
MUC1 protein structure - 53-9893-80 shown in red.