Antibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations
- Immunohistochemistry [6]
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- Product number
- NBP1-88552 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-88552, RRID:AB_11017013
- Product name
- Rabbit Polyclonal GRHL2 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human GRHL2 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Grainyhead-like 2 Promotes Tumor Growth and is Associated with Poor Prognosis in Colorectal Cancer.
Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer.
Integrative bioinformatics analysis reveals new prognostic biomarkers of clear cell renal cell carcinoma.
Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.
Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1.
Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2.
Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected].
The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.
Quan Y, Xu M, Cui P, Ye M, Zhuang B, Min Z
Journal of Cancer 2015;6(4):342-50
Journal of Cancer 2015;6(4):342-50
Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer.
Torres-Reyes LA, Alvarado-Ruiz L, Piña-Sánchez P, Martínez-Silva MG, Ramos-Solano M, Olimón-Andalón V, Ortiz-Lazareno PC, Hernández-Flores G, Bravo-Cuellar A, Aguilar-Lemarroy A, Jave-Suarez LF
International journal of clinical and experimental pathology 2014;7(11):7409-18
International journal of clinical and experimental pathology 2014;7(11):7409-18
Integrative bioinformatics analysis reveals new prognostic biomarkers of clear cell renal cell carcinoma.
Butz H, Szabó PM, Nofech-Mozes R, Rotondo F, Kovacs K, Mirham L, Girgis H, Boles D, Patocs A, Yousef GM
Clinical chemistry 2014 Oct;60(10):1314-26
Clinical chemistry 2014 Oct;60(10):1314-26
Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis.
Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D
American journal of physiology. Lung cellular and molecular physiology 2014 Mar 1;306(5):L405-19
American journal of physiology. Lung cellular and molecular physiology 2014 Mar 1;306(5):L405-19
Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1.
Quan Y, Jin R, Huang A, Zhao H, Feng B, Zang L, Zheng M
Cancer biology & therapy 2014 Jul;15(7):878-87
Cancer biology & therapy 2014 Jul;15(7):878-87
Epithelial-mesenchymal transition and tumor suppression are controlled by a reciprocal feedback loop between ZEB1 and Grainyhead-like-2.
Cieply B, Farris J, Denvir J, Ford HL, Frisch SM
Cancer research 2013 Oct 15;73(20):6299-309
Cancer research 2013 Oct 15;73(20):6299-309
Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epithelium.[corrected].
Gao X, Vockley CM, Pauli F, Newberry KM, Xue Y, Randell SH, Reddy TE, Hogan BL
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 4;110(23):9356-61
Proceedings of the National Academy of Sciences of the United States of America 2013 Jun 4;110(23):9356-61
The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation.
Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI
The Journal of biological chemistry 2012 Oct 26;287(44):37282-95
The Journal of biological chemistry 2012 Oct 26;287(44):37282-95
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human urinary bladder shows strong nuclear positivity in urothelial cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human skin shows strong nuclear positivity in squamous epithelial cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human prostate shows strong nuclear positivity in glandular cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human liver shows no positivity as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human urinary bladder shows strong nuclear positivity in urothelial cells.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: GRHL2 Antibody [NBP1-88552] - Staining of human skin shows strong nuclear positivity in squamous epithelial cells.