MAB1264

antibody from R&D Systems

Targeting: PDGFRA CD140a, GAS9, PDGFR2

Immunoprecipitation (Data presented on provider website)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

MAB1264

Provider

R&D Systems

Product name

Human PDGF R alpha Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from ascites. Detects human PDGF R alpha . Recognizes the PDGF receptor alpha-subunit; it does not recognize the PDGF receptor beta-subunit. Binds to the PDGF receptor alpha-subunit of primate species (human, monkey, baboon) and dog. Does not recognize rat or mouse receptors and its ability to bind to receptors from other species has not been tested.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

PRa292

Vial size

250 ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C, as supplied. 1 month, 2 to 8 °C under sterile conditions after opening. 6 months, -20 to -70 °C under sterile conditions after opening.

References

Submitted references

A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma.

Stringer BW, Day BW, D'Souza RCJ, Jamieson PR, Ensbey KS, Bruce ZC, Lim YC, Goasdoué K, Offenhäuser C, Akgül S, Allan S, Robertson T, Lucas P, Tollesson G, Campbell S, Winter C, Do H, Dobrovic A, Inglis PL, Jeffree RL, Johns TG, Boyd AW
Scientific reports 2019 Mar 20;9(1):4902

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PDGFRA alterations in cancer: characterization of a gain-of-function V536E transmembrane mutant as well as loss-of-function and passenger mutations.

Velghe AI, Van Cauwenberghe S, Polyansky AA, Chand D, Montano-Almendras CP, Charni S, Hallberg B, Essaghir A, Demoulin JB
Oncogene 2014 May 15;33(20):2568-76

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Alveolar macrophages are critical for the inhibition of allergic asthma by mesenchymal stromal cells.

Mathias LJ, Khong SM, Spyroglou L, Payne NL, Siatskas C, Thorburn AN, Boyd RL, Heng TS
Journal of immunology (Baltimore, Md. : 1950) 2013 Dec 15;191(12):5914-24

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Mesenchymal stem cell abnormalities in patients with multiple myeloma.

Garderet L, Mazurier C, Chapel A, Ernou I, Boutin L, Holy X, Gorin NC, Lopez M, Doucet C, Lataillade JJ
Leukemia & lymphoma 2007 Oct;48(10):2032-41

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Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor.

Zhang M, Veselits M, O'Neill S, Hou P, Reddi AL, Berlin I, Ikeda M, Nash PD, Longnecker R, Band H, Clark MR
Journal of immunology (Baltimore, Md. : 1950) 2007 Oct 1;179(7):4435-43

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Ubiquitinylation of Ig beta dictates the endocytic fate of the B cell antigen receptor.

Zhang M, Veselits M, O'Neill S, Hou P, Reddi AL, Berlin I, Ikeda M, Nash PD, Longnecker R, Band H, Clark MR
Journal of immunology (Baltimore, Md. : 1950) 2007 Oct 1;179(7):4435-43

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Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.

Ball SG, Shuttleworth CA, Kielty CM
The Journal of cell biology 2007 May 7;177(3):489-500

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The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.

Ponte AL, Marais E, Gallay N, Langonné A, Delorme B, Hérault O, Charbord P, Domenech J
Stem cells (Dayton, Ohio) 2007 Jul;25(7):1737-45