DCABH-5352

antibody from Creative Diagnostics

Targeting: KRT2 KRT2A, KRTE

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

DCABH-5352

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-5352, RRID:AB_2478986

Product name

Rabbit Anti-Human KRT2 monoclonal antibody, clone KK312-9

Antibody type

Monoclonal

Description

The keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair keratins are responsible for creating nails and hair. There are two types of keratins: the acidic class I keratin proteins and the basic/neutral class II keratin proteins. Keratin 2 (KRT2), also known as Keratin type II cytoskeletal 2 epidermal, Keratin-2e (K2e), KRTE, Cytokeratin-2e (CK-2e), KRT2A or KRT2E, is a 639 amino acid class II epithelial Keratin protein belonging to the intermediate filament family. Encoded by a gene that maps to human chromosome 12q13.13, Keratin 2 functions in epidermal keratinocyte activation and proliferation, and plays a part in terminal cornification. Highly expressed in upper epithelial tissues, Keratin 2 forms heterotetramers with two class I Keratins and another class II Keratin. Defects in Keratin 2 have been linked to ichthyosis bullosa of Siemens (IBS), a rare autosomal dominant skin disorder.

Reactivity

Human

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

KK312-9

Vial size

100 _l

Storage

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.