BAF2420

antibody from Novus Biologicals

Targeting: GRN CLN11, PCDGF, PGRN

Western blot (Data presented on provider website)

Antibody Data

Product number

BAF2420

Provider

Novus Biologicals

Product name

Goat Polyclonal Progranulin/PGRN Antibody

Antibody type

Polyclonal

References

Submitted references

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, Bartenstein P, Rominger A, Tahirovic S, Smith ST, Madore C, Butovsky O, Capell A, Haass C
EMBO molecular medicine 2019 Jun;11(6)

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CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline.

Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Jucker M, Masters CL, Rossor MN, Ringman JM, Shaw LM, Trojanowski JQ, Weiner M, Ewers M, Haass C, Dominantly Inherited Alzheimer Network, Alzheimer's Disease Neuroimaging Initiative
EMBO molecular medicine 2018 Dec;10(12)

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Serum biomarker for progranulin-associated frontotemporal lobar degeneration.

Sleegers K, Brouwers N, Van Damme P, Engelborghs S, Gijselinck I, van der Zee J, Peeters K, Mattheijssens M, Cruts M, Vandenberghe R, De Deyn PP, Robberecht W, Van Broeckhoven C
Annals of neurology 2009 May;65(5):603-9

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Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival.

Van Damme P, Van Hoecke A, Lambrechts D, Vanacker P, Bogaert E, van Swieten J, Carmeliet P, Van Den Bosch L, Robberecht W
The Journal of cell biology 2008 Apr 7;181(1):37-41