Antibody data
- Antibody Data
- Antigen structure
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- Product number
- 631302 - Provider product page
- Provider
- BioLegend
- Product name
- Purified anti-Daxx
- Antibody type
- Monoclonal
- Antigen
- Peptide corresponding to amino acids 558-740 of human Daxx.
- Description
- The DAXX-01 monoclonal antibody recognizes human Daxx also known as Death domain-associated protein 6 and EAP1. Daxx is a ubiquitously expressed protein with a predicted molecular weight approximately 81 kD. Daxx binds to both Fas death domain and the apoptosis signal-regulating kinase 1 (ASK1) and promotes Fas-mediated apoptosis through a signal transduction pathway involving the Jun amino-terminal kinase(JNK) pathway. Daxx is mainly located in the nucleus as a transcriptional repressor and also located in the cytoplasmic as a proapoptotic signal mediator. The DAXX-01 antibody has been shown to be useful for Western blotting and Immunocytochemistry. Daxx migrated with an apparent molecular weight of approximately 120 kD on SDS-PAGE; this slower than expected migration may reflect the high content of acidic residues in Daxx.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
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