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antibody from antibodies-online
Targeting: KEAP1
INrf2, KIAA0132, KLHL19, MGC10630, MGC1114, MGC20887, MGC4407, MGC9454
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- ABIN1449975 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Kelch-Like ECH-Associated Protein 1 (KEAP1) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- A 19 amino acid synthetic peptide near the carboxy terminus of Human KEAP1
- Description
- Affinity chromatography purified via peptide column
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Epitope
- C-Term
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1.0 mg/mL
- Storage
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells.
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Jiang J, Mo ZC, Yin K, Zhao GJ, Lv YC, Ouyang XP, Jiang ZS, Fu Y, Tang CK
International journal of molecular medicine 2012 May;29(5):946-56
International journal of molecular medicine 2012 May;29(5):946-56
Utility of siRNA against Keap1 as a strategy to stimulate a cancer chemopreventive phenotype.
Devling TW, Lindsay CD, McLellan LI, McMahon M, Hayes JD
Proceedings of the National Academy of Sciences of the United States of America 2005 May 17;102(20):7280-7285A
Proceedings of the National Academy of Sciences of the United States of America 2005 May 17;102(20):7280-7285A
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.
Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M
Molecular and cellular biology 2004 Dec;24(24):10941-53
Molecular and cellular biology 2004 Dec;24(24):10941-53
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Kobayashi A, Kang MI, Okawa H, Ohtsuji M, Zenke Y, Chiba T, Igarashi K, Yamamoto M
Molecular and cellular biology 2004 Aug;24(16):7130-9
Molecular and cellular biology 2004 Aug;24(16):7130-9
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Supportive validation
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- Main image
- Experimental details
- Western blot analysis of KEAP1 in human lung tissue lysate with KEAP1 antibody Cat.-No AP55471PU-N at (A) 1 and (B) 2 ?g/ml.
