Explore
Validate
Learn
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 358512 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#358512, RRID:AB_2566196
- Product name
- PE/Cy7 anti-human/mouse Bcl-6
- Antibody type
- Monoclonal
- Antigen
- Sequence 226-398 of murine BLC6 fused with GST
- Description
- B-cell lymphoma 6 (Bcl-6), is an 80 kD homodimer, member of the BTB-POZ zinc finger family. It contains 1 BTB (POZ) domain and 6 C2H2-type zinc fingers. Bcl-6 is a transcriptional repressor, master regulator of germinal center reaction. On B cells, Bcl-6 induces proliferation, antibody class switch and affinity maturation, while inhibits its differentiation to plasma cells. On T cells, Bcl-6 induces its differentiation to TFH. This molecule is also expressed in some B cell lymphomas and breast cancer cells.
- Reactivity
- Human, Mouse
- Host
- Rat
- Conjugate
- Near infrared dye
- Antibody clone number
- 7D1
- Vial size
- 100 tests
- Storage
- 2°C-8°C
- Handling
- Ambient RT
No comments: Submit comment
Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Burkitt?s lymphoma cell line, Ramos, was stained with Bcl-6 (clone 7D1) PE/Cy7 (filled histogram) or rat IgG2a, κ PE/Cy7 isotype control (open histogram).
- Conjugate
- Near infrared dye
