BS7158

antibody from Bioworld Technology, Inc
Targeting: MCM4 CDC21, CDC54, hCdc21, MGC33310, P1-Cdc21
Provider product page for BS7158
Western blot
Immunohistochemistry

Antibody data

Product number
BS7158 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MCM4 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MCM4 .
Description
The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2-6) during apoptosis. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity, and MCM5 is involved in IFN-ÎÛ-induced Stat1Ï« transcription activation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MCM4 protein structure - BS7158 shown in red.