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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB995A - Provider product page
- Provider
- R&D Systems
- Product name
- Human ABCG2 APC-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human ABCG2 in flow cytometry and immunocytochemistry.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Antibody clone number
- 5D3
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Stem cell-like side populations in esophageal cancer: a source of chemotherapy resistance and metastases.
Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter.
MDR1 expression identifies human melanoma stem cells.
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
Zhao Y, Bao Q, Schwarz B, Zhao L, Mysliwietz J, Ellwart J, Renner A, Hirner H, Niess H, Camaj P, Angele M, Gros S, Izbicki J, Jauch KW, Nelson PJ, Bruns CJ
Stem cells and development 2014 Jan 15;23(2):180-92
Stem cells and development 2014 Jan 15;23(2):180-92
Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
Gojo I, Tan M, Fang HB, Sadowska M, Lapidus R, Baer MR, Carrier F, Beumer JH, Anyang BN, Srivastava RK, Espinoza-Delgado I, Ross DD
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Apr 1;19(7):1838-51
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Apr 1;19(7):1838-51
Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter.
Ozvegy-Laczka C, Laczkó R, Hegedus C, Litman T, Várady G, Goda K, Hegedus T, Dokholyan NV, Sorrentino BP, Váradi A, Sarkadi B
The Journal of biological chemistry 2008 Sep 19;283(38):26059-70
The Journal of biological chemistry 2008 Sep 19;283(38):26059-70
MDR1 expression identifies human melanoma stem cells.
Keshet GI, Goldstein I, Itzhaki O, Cesarkas K, Shenhav L, Yakirevitch A, Treves AJ, Schachter J, Amariglio N, Rechavi G
Biochemical and biophysical research communications 2008 Apr 18;368(4):930-6
Biochemical and biophysical research communications 2008 Apr 18;368(4):930-6
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.
Bram EE, Ifergan I, Grimberg M, Lemke K, Skladanowski A, Assaraf YG
Biochemical pharmacology 2007 Jun 30;74(1):41-53
Biochemical pharmacology 2007 Jun 30;74(1):41-53
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Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of ABCG2 in MCF-7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human ABCG2 APC-conjugated Monoclonal Antibody (Catalog # FAB995A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.
