11-0189-42

antibody from Invitrogen Antibodies

Targeting: ITGB2 CD18, LFA-1, MAC-1, MFI7

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

11-0189-42

Provider

Invitrogen Antibodies

Product name

CD18 (LFA-1 beta) Monoclonal Antibody (6.7), FITC, eBioscience™

Antibody type

Monoclonal

Antigen

Other

Description

Description: The 6.7 monoclonal antibody reacts with human and non-human primate (rhesus or cynomologus) CD18, which is also known as beta2 integrin. CD18 is a 90-95 kDa type I transmembrane protein that heterodimerizes with the a chain of CD11a, CD11b and CD11c. The CD18/CD11a complex is also known as lymphocyte function-associated antigen-1 (LFA-1) and plays an important role in cellular adhesion and inflammatory reactions. CD18 is expressed broadly by human lymphocytes and monocytes. Peripheral blood granulocytes also express CD18, but at lower levels.

Conjugate

Green dye

Antibody clone number

6.7

Concentration

5 µL/Test

References

Submitted references

Proliferation of resting lymphocytes is induced by triggering T cells through an epitope common to the three CD18/CD11 leukocyte adhesion molecules.

David V, Leca G, Corvaia N, Le Deist F, Boumsell L, Bensussan A
Cellular immunology 1991 Sep;136(2):519-24

Flow cytometry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (blue histogram) or Anti-Human/Non-Human Primate CD18 FITC (purple histogram). Cells in the lymphocyte gate were used for analysis.

Conjugate

Green dye