10-4168-F-25

antibody from ABEOMICS Inc.
Targeting: SLC3A2 4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
Provider product page for 10-4168-F-25

Antibody data

Product number
10-4168-F-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-Human CD98 Antibody
Antibody type
Monoclonal
Description
CD98 was originally identified as a cell surface antigen associated with lymphocyte activation defined by 4F2 mAb; it is expressed in proliferating normal tissues and in almost all tumor cells. CD98 heterodimer consists of a type II single-pass transmembrane heavy chain (CD98hc, also known as 4F2 antigen heavy chain or FRP-1; encoded by the genes SLC3A2 and Slc3a2 for human and mouse, respectively) of ~80–85 kDa that is disulfide-linked with a multi-pass light chain of ~40 kDa. CD98 hc (heavy chain) is a type II transmembrane glycoprotein that is disulfide-linked to a non-glycosylated light chain of a member of the permease family. It has been reported that CD98 was functionally involved in lymphocyte activation, cell proliferation, and malignant transformation. CD98 forms the large neutral amino acid transporter that is a heterodimeric membrane transport protein to transport branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids. Intestinal epithelial cells express CD98 under the physiological conditions. Recent reports indicate that CD98 is involved in the intestinal inflammation, which can be upregulated by interferon (IFN)-gamma in the intestine.
Reactivity
Human
Host
Mouse
Conjugate
Green dye
Antigen sequence
A partial length recombinant protei
n (a.a 162-371) of hCD98 was use
d as the immunogen for this antibod
y.
Isotype
IgG
Antibody clone number
ABM5A27
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
SLC3A2 protein structure - 10-4168-F-25 shown in red.