RB-02-0028B-50

antibody from RayBiotech, Inc.
Targeting: BIRC7 KIAP, ML-IAP, mliap, RNF50
Provider product page for RB-02-0028B-50
Western blot
ELISA

Antibody data

Product number
RB-02-0028B-50 - Provider product page
Provider
RayBiotech, Inc.
Product name
Rabbit Anti-Human Livin [+Biotin]
Antibody type
Polyclonal
Antigen
a synthetic peptide (Livin).
Description
Livin is a member of the inhibitors of apoptosis (IAP) family, which plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Livin (BIRC7/ML-IAP) contains a single BIR domain and RING finger motif that is highly expressed in human melanomas and absent in normal tissues. It is localized in the nucleus and diffusely in the cytoplasm. The livin gene encodes two splicing variants, a 298 amino acid isoform (?) and a 280 amino acid form (?), with different biological activity to various apoptotic stimuli. In addition to directly inhibiting caspase activity, livin can promote the degradation of the proapoptotic protein Smac through the ubiquitin-proteasome pathway. This antibody was produced from a rabbit immunized with this peptide conjugated with KLH. The IgG fraction was purified from rabbit serum by Protein G affinity chromatography.
Reactivity
Human
Host
Rabbit
Conjugate
Biotin
Antigen sequence
This antibody was produced from a r
abbit immunized with this peptide c
onjugated with KLH. The IgG fractio
n was purified from rabbit serum by
Protein G affinity chromatography.
Isotype
IgG
Vial size
50 µg
Handling
Product is supplied as a powder obtained from lyophilization of purified antibody in PBS without preservatives. Reconstitute the antibody with sterile 1 x PBS to a final concentration of 1 mg/ml.
BIRC7 protein structure - RB-02-0028B-50 shown in red.