53-9047-42

antibody from Invitrogen Antibodies
Targeting: MCL1 BCL2L3, Mcl-1
Provider product page for 53-9047-42

Antibody data

Product number
53-9047-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
MCL-1 Monoclonal Antibody (LVUBKM), Alexa Fluor™ 488, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This LVUBKM monoclonal antibody recognizes human and mouse myeloid cell leukemia sequence 1 (Mcl-1). Mcl-1 is an anti-apoptotic member of the Bcl-2 family of proteins important for regulation of cell survival/apoptosis. Mcl-1 is primarily localized to the outer membrane of mitochondria where it prevents cytochrome c release via dimerization with other Bcl-2 family members such as Bim. Although it is expressed in both immune and non-immune cells, highest levels of Mcl-1 expression are seen in hematopoietic lineage cells. PI3K activation of AKT results in destabilization and degradation of GSK3 beta, which prevents phosphorylation of Mcl-1 on S159 and its subsequent ubiquitnation and degradation. Mice conditionally lacking Mcl-1 in lymphocytes showed that Mcl-1 is essential during early lymphoid development and for the maintenance of mature lymphocytes.
Conjugate
Green dye
Antibody clone number
LVUBKM
Concentration
5 µL/Test
MCL1 protein structure - 53-9047-42 shown in red.