WISP1

gene product
CCN4
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
256 antibodies from 32 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
Invitrogen Antibodies
3 antibodies
Novus Biologicals
13 antibodies
LifeSpan BioSciences, Inc.
38 antibodies
Abnova Corporation
5 antibodies
NovoPro Bioscience Inc.
2 antibodies
NSJ Bioreagents
2 antibodies
GeneTex
4 antibodies
R&D Systems
7 antibodies
antibodies-online
63 antibodies
Proteintech Group
1 antibody
Boster Biological Technology
1 antibody
Biorbyt
11 antibodies
Acris Antibodies GmbH
6 antibodies
OriGene
5 antibodies
Aviva Systems Biology
3 antibodies
Atlas Antibodies
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
Affinity Biosciences
1 antibody
Antibodies.com
1 antibody
Everest Biotech
1 antibody
MyBioSource
9 antibodies
ProSci
3 antibodies
Arigo
1 antibody
Creative Diagnostics
4 antibodies
St John's Laboratory
3 antibodies
United States Biological
22 antibodies
Sigma-Aldrich
3 antibodies
EMD Millipore
1 antibody
RayBiotech, Inc.
1 antibody
Creative Biolabs
13 antibodies
Abbexa
3 antibodies