514203

antibody from BioLegend

Targeting: IL21 IL-21, Za11

Western blot (Data presented on provider website)

Antibody Data

Product number

514203

Provider

BioLegend

Proper citation

BioLegend Cat#514203, RRID:AB_1227667

Product name

Biotin anti-human/mouse IL-21

Antibody type

Monoclonal

Antigen

Recombinant full length human IL-21

Description

Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses.  These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells.  It can also be proapoptotic for B cells and NK cells.  Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Biotin

Isotype

IgG

Vial size

50 µg

Concentration

0.5 mg/ml

Storage

Upon receipt, store frozen at 4°C.