BS5063

antibody from Bioworld Technology, Inc

Targeting: CFL1 CFL

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

BS5063

Provider

Bioworld Technology, Inc

Proper citation

Bioworld Technology Cat#BS5063, RRID:AB_1662020

Product name

Cofilin 1 (phospho S3) polyclonal antibody

Antibody type

Polyclonal

Antigen

Synthetic phosphopeptide derived from human Cofilin 1 around the phosphorylation site of Serine 3.

Description

Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly, essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous F-Actin by bridging two longitudinally-associated Actin subunits, changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser 3 by factors like opsonized zymosan. LIM kinase 1 (LIMK-1), a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerize F-Actin.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.