MB0139

antibody from Bioworld Technology, Inc
Targeting: GRK2 ADRBK1, BARK1
Provider product page for MB0139

Antibody data

Product number
MB0139 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GRK 2 / ADRBK1 monoclonal antibody
Antibody type
Monoclonal
Antigen
Recombinant full length Human GRK 2 / ADRBK1.
Description
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonistmediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first are the second messenger-regulated kinases such as c-AMP dependent protein kinase A and protein kinase C. The second are the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase, GRK 1; two forms of ÉÇ-adrenergic receptor kinase, GRK 2 (ÉÇARK, ÉÇARK1) and GRK 3 (ÉÇARK2); IT-11 (GRK 4); GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Reactivity
Human, Mouse
Host
Mouse
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GRK2 protein structure - MB0139 shown in red.