CABT-BL7695

antibody from Creative Diagnostics

Targeting: IL12B CLMF, CLMF2, IL-12B, NKSF, NKSF2

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL7695

Provider

Creative Diagnostics

Product name

Anti-IL12B Monoclonal antibody, clone IQ50 [eFluor? 660]

Antibody type

Monoclonal

Description

IL-23 is a member of the IL-12 cytokine family which is produced by dendritic cells and other antigen presenting cells in the peripheral tissues. This cytokine is a heterodimer composed of an IL-12p40 subunit, and a p19 subunit. IL-23 plays an important role in stimulating memory T-cells. It is also required for the induction, expansion, maintenance, and downstream effector functions of Th17 cells. Th17 cells play a vital role in upregulating neutrophil chemokines and various pro-inflammatory cytokines. IL-23 interacts with the receptors IL-12R beta1 and IL-23R to activate the Jak-Stat signaling cascade.

Reactivity

Human

Host

Mouse

Isotype

IgG