14-7129-81

antibody from Invitrogen Antibodies
Targeting: IL23A IL-23, IL-23A, IL23P19, P19, SGRF
Provider product page for 14-7129-81
Western blot
Flow cytometry
Blocking/Neutralizing
Other assay

Antibody data

Product number
14-7129-81 - Provider product page
Provider
Invitrogen Antibodies
Product name
Anti-IL-12/IL-23 p40 Monoclonal Antibody (C8.6), eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The C8.6 antibody reacts with the p40 subunit of human IL-12 p70 and human IL-23. IL-12 is a 70 kDa heterodimeric cytokine composed of two covalently linked chains, p40 and p35, and secreted primarily by activated monocytes, macrophages, and dendritic cells. IL-23 is a biologically-related, heterodimeric cytokine composed of disulfide-linked p40 and p19 subunits. Applications Reported: Unlabeled C8.6 has been reported for use as a cold mAb control to block fluorochrome conjugated C8.6 in staining of intracellular IL-12 and in immunblotting under nonreducing conditions. C8.6 has also been reported for use in cytokine neutralization. (Please use Functional Grade purified C8.6, cat. 16-7129, in functional assays.). Applications Tested: The unconjugated C8.6 antibody has been tested as a cold mAb control to block fluorochrome conjugated C8.6 in staining of intracellular IL-12 and nonreducing immunoblots at 2 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered.
Reactivity
Human
Host
Mouse
Isotype
IgG
Antibody clone number
C8.6
Vial size
50 µg
Concentration
0.5 mg/mL
Storage
4° C
IL23A protein structure - 14-7129-81 shown in red.