ABIN1673683

antibody from antibodies-online

Targeting: IRAK3 IRAK-M

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN1673683

Provider

antibodies-online

Product name

anti-Interleukin-1 Receptor-Associated Kinase 3 (IRAK3) (C-Term) antibody

Antibody type

Polyclonal

Antigen

A synthetic peptide corresponding to a sequence at the C-terminus of mouse IRAK3, identical to the related rat sequence, and different from the related human sequence by one amino acid.Immunogen affinity purified.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

C-Term

Isotype

IgG

Vial size

100 μg

Storage

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

IRAK-M is involved in the pathogenesis of early-onset persistent asthma.

Balaci L, Spada MC, Olla N, Sole G, Loddo L, Anedda F, Naitza S, Zuncheddu MA, Maschio A, Altea D, Uda M, Pilia S, Sanna S, Masala M, Crisponi L, Fattori M, Devoto M, Doratiotto S, Rassu S, Mereu S, Giua E, Cadeddu NG, Atzeni R, Pelosi U, Corrias A, Perra R, Torrazza PL, Pirina P, Ginesu F, Marcias S, Schintu MG, Del Giacco GS, Manconi PE, Malerba G, Bisognin A, Trabetti E, Boner A, Pescollderungg L, Pignatti PF, Schlessinger D, Cao A, Pilia G
American journal of human genetics 2007 Jun;80(6):1103-14

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Sepsis-induced suppression of lung innate immunity is mediated by IRAK-M.

Deng JC, Cheng G, Newstead MW, Zeng X, Kobayashi K, Flavell RA, Standiford TJ
The Journal of clinical investigation 2006 Sep;116(9):2532-42

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IRAK-M is a negative regulator of Toll-like receptor signaling.

Kobayashi K, Hernandez LD, Galán JE, Janeway CA Jr, Medzhitov R, Flavell RA
Cell 2002 Jul 26;110(2):191-202