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- Antibody Data
- Antigen structure
- References [91]
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- Immunocytochemistry [1]
- Immunohistochemistry [1]
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- Product number
- MA5-16393 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Progesterone Receptor Monoclonal Antibody (SP2)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is breast ductal carcinoma.
- Reactivity
- Human, Rat
- Host
- Rabbit
- Isotype
- IgG
- Antibody clone number
- SP2
- Vial size
- 500 µL
- Concentration
- 0.08 mg/mL
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Submitted references Integrative Analyses of Uterine Transcriptome and MicroRNAome Reveal Compromised LIF-STAT3 Signaling and Progesterone Response in the Endometrium of Patients with Recurrent/Repeated Implantation Failure (RIF).
Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer.
Runx2 Expression as a Potential Prognostic Marker in Invasive Ductal Breast Carcinoma.
Attempt towards a novel classification of triple-negative breast cancer using immunohistochemical markers.
Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer.
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast: CD44/CD24 expression in breast cancer.
Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature.
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Epstein-Barr virus-associated lymphoepithelioma-like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome.
Comparison of estrogen receptor-α, progesterone receptor and calponin expression in gonadotrophin-releasing hormone agonist-sensitive and -resistant uterine fibroids.
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer.
T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant.
Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer.
Lack of correlation of stem cell markers in breast cancer stem cells.
ER, PR, HER2, Ki-67 and CK5 in Early and Late Relapsing Breast Cancer-Reduced CK5 Expression in Metastases.
An associated classification of triple negative breast cancer: the risk of relapse and the response to chemotherapy.
AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients.
Biological and demographic profile of meningiomas in a cohort of Egyptian patients: impact on tumor recurrence.
Cyclooxygenase-2 169C>G and 8473T>C gene polymorphisms and prostaglandin E2 level in breast cancer: a case-control study.
Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration.
The prognostic significance of metaplastic carcinoma of the breast (MCB)--a case controlled comparison study with infiltrating ductal carcinoma.
The prognostic role of preoperative and (early) postoperatively change in CA15.3 serum levels in a single hospital cohort of primary operable breast cancers.
Selective suppression of endothelial cytokine production by progesterone receptor.
Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features.
Quantification of ER/PR expression in ovarian low-grade serous carcinoma.
TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression.
Prognostic comparison of the proliferation markers (mitotic activity index, phosphohistone H3, Ki67), steroid receptors, HER2, high molecular weight cytokeratins and classical prognostic factors in T₁₋₂N₀M₀ breast cancer.
Prognostic comparison of the proliferation markers (mitotic activity index, phosphohistone H3, Ki67), steroid receptors, HER2, high molecular weight cytokeratins and classical prognostic factors in T₁₋₂N₀M₀ breast cancer.
Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature.
Pregnancy-related peritoneal ectopic decidua (deciduosis): morphological and clinical evaluation.
Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review.
Survival benefit of tamoxifen in estrogen receptor-negative and progesterone receptor-positive low grade breast cancer patients.
The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer.
Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab.
Applying the 2011 St Gallen panel of prognostic markers on a large single hospital cohort of consecutively treated primary operable breast cancers.
Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients.
Free circulating tumor DNA as a diagnostic marker for breast cancer.
Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure.
A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin and trastuzumab for T2 breast cancers.
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
A 10-year follow-up of triple-negative breast cancer patients in Taiwan.
MiR-34b is associated with clinical outcome in triple-negative breast cancer patients.
Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases.
Investigation of immunohistochemical ERα, ERβ and ERβcx expressions in normal and neoplastic breast tissues.
Cytologic features of triple-negative breast carcinoma.
The pathologic characteristics of breast cancer in China and its shift during 1999-2008: a national-wide multicenter cross-sectional image over 10 years.
Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report.
Stromal caveolin-1 expression in breast carcinoma. Correlation with early tumor recurrence and clinical outcome.
Wilms tumor-1, claudin-1 and ezrin are useful immunohistochemical markers that help to distinguish schwannoma from fibroblastic meningioma.
Clinical significance of KISS1 protein expression for brain invasion and metastasis.
Clinical and pathological features of breast cancer associated with the pathological complete response to anthracycline-based neoadjuvant chemotherapy.
Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.
Correlation of HER 2/neu gene amplification with immunohistochemistry and other prognostic factors in breast carcinoma.
Overexpression of α-enolase correlates with poor survival in canine mammary carcinoma.
Association between hormone receptor expression and epidermal growth factor receptor mutation in patients operated on for non-small cell lung cancer.
May metaplastic breast carcinomas be actually basal-like carcinoma? Further evidence study with its ultrastructure and survival analysis.
Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
Prognostic significance of triple negative breast cancer at tumor size 1 cm and smaller.
A case of prostatic adenocarcinoma with aberrant p63 expression: presentation with detailed immunohistochemical study and FISH analysis.
Ectopic endometrial tissue in mesonephric duct remnants in bitches.
Correlation of histologic grade with other clinicopathological parameters, intrinsic subtype, and patients' clinical outcome in Taiwanese women.
Recurrence of benign meningiomas: predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression.
Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases.
Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors.
p16INK4a expression in basal-like breast carcinoma.
Pseudo-placentational endometrial cysts in a bitch.
Papillary apocrine metaplasia and columnar cell lesion with atypia: is there a shared common pathway?
Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients.
Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs).
Triple negative breast carcinoma is a prognostic factor in Taiwanese women.
Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive.
A three-dimensional culture model of canine uterine glands.
Identification of CD44v6(+)/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies.
Rabbit monoclonal antibodies show higher sensitivity than mouse monoclonals for estrogen and progesterone receptor evaluation in breast cancer by immunohistochemistry.
Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer.
Prognostic relevance of androgen receptor detection in operable breast cancer.
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts.
Expression of c-kit proto-oncogene product in breast cancer tissues.
Expression of c-kit proto-oncogene product in breast cancer tissues.
Matrix metalloproteinase expression patterns in luminal A type breast carcinomas.
Matrix metalloproteinase expression patterns in luminal A type breast carcinomas.
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature.
Prognostic factors in Hungarian breast cancer patients.
A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer.
Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study.
Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient.
Primary squamous cell carcinoma of the endometrium: a case report with immunohistochemical and molecular study.
Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line.
Choi Y, Kim HR, Lim EJ, Park M, Yoon JA, Kim YS, Kim EK, Shin JE, Kim JH, Kwon H, Song H, Choi DH
PloS one 2016;11(6):e0157696
PloS one 2016;11(6):e0157696
Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer.
Sheen MR, Marotti JD, Allegrezza MJ, Rutkowski M, Conejo-Garcia JR, Fiering S
Oncogenesis 2016 Oct 31;5(10):e267
Oncogenesis 2016 Oct 31;5(10):e267
Runx2 Expression as a Potential Prognostic Marker in Invasive Ductal Breast Carcinoma.
El-Gendi SM, Mostafa MF
Pathology oncology research : POR 2016 Jul;22(3):461-70
Pathology oncology research : POR 2016 Jul;22(3):461-70
Attempt towards a novel classification of triple-negative breast cancer using immunohistochemical markers.
Liu YX, Wang KR, Xing H, Zhai XJ, Wang LP, Wang W
Oncology letters 2016 Aug;12(2):1240-1256
Oncology letters 2016 Aug;12(2):1240-1256
Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer.
Matsumoto H, Thike AA, Li H, Yeong J, Koo SL, Dent RA, Tan PH, Iqbal J
Breast cancer research and treatment 2016 Apr;156(2):237-47
Breast cancer research and treatment 2016 Apr;156(2):237-47
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
Koren S, Reavie L, Couto JP, De Silva D, Stadler MB, Roloff T, Britschgi A, Eichlisberger T, Kohler H, Aina O, Cardiff RD, Bentires-Alj M
Nature 2015 Sep 3;525(7567):114-8
Nature 2015 Sep 3;525(7567):114-8
The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast: CD44/CD24 expression in breast cancer.
Kapucuoğlu N, Bozkurt KK, Başpınar Ş, Koçer M, Eroğlu HE, Akdeniz R, Akçil M
Pathology, research and practice 2015 Oct;211(10):740-7
Pathology, research and practice 2015 Oct;211(10):740-7
Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature.
Ertoy Baydar D, Kosemehmetoglu K, Aydin O, Bridge JA, Buyukeren B, Aki FT
Diagnostic pathology 2015 Oct 9;10:186
Diagnostic pathology 2015 Oct 9;10:186
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Hole S, Pedersen AM, Hansen SK, Lundqvist J, Yde CW, Lykkesfeldt AE
International journal of oncology 2015 Apr;46(4):1481-90
International journal of oncology 2015 Apr;46(4):1481-90
Epstein-Barr virus-associated lymphoepithelioma-like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome.
Chan AW, Tong JH, Sung MY, Lai PB, To KF
Histopathology 2014 Nov;65(5):674-83
Histopathology 2014 Nov;65(5):674-83
Comparison of estrogen receptor-α, progesterone receptor and calponin expression in gonadotrophin-releasing hormone agonist-sensitive and -resistant uterine fibroids.
Kim EH, Kim JY, Lee YH, Chong GO, Park JY, Hong DG
Obstetrics & gynecology science 2014 Mar;57(2):144-50
Obstetrics & gynecology science 2014 Mar;57(2):144-50
The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma.
von Figura G, Fukuda A, Roy N, Liku ME, Morris Iv JP, Kim GE, Russ HA, Firpo MA, Mulvihill SJ, Dawson DW, Ferrer J, Mueller WF, Busch A, Hertel KJ, Hebrok M
Nature cell biology 2014 Mar;16(3):255-67
Nature cell biology 2014 Mar;16(3):255-67
Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer.
Dean SJ, Perks CM, Holly JM, Bhoo-Pathy N, Looi LM, Mohammed NA, Mun KS, Teo SH, Koobotse MO, Yip CH, Rhodes A
American journal of clinical pathology 2014 Mar;141(3):323-33
American journal of clinical pathology 2014 Mar;141(3):323-33
T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant.
Kirkegaard T, Hansen SK, Larsen SL, Reiter BE, Sørensen BS, Lykkesfeldt AE
Cancer letters 2014 Mar 1;344(1):90-100
Cancer letters 2014 Mar 1;344(1):90-100
Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation.
Goddard LM, Murphy TJ, Org T, Enciso JM, Hashimoto-Partyka MK, Warren CM, Domigan CK, McDonald AI, He H, Sanchez LA, Allen NC, Orsenigo F, Chao LC, Dejana E, Tontonoz P, Mikkola HK, Iruela-Arispe ML
Cell 2014 Jan 30;156(3):549-62
Cell 2014 Jan 30;156(3):549-62
Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer.
Dong P, Kaneuchi M, Xiong Y, Cao L, Cai M, Liu X, Guo SW, Ju J, Jia N, Konno Y, Watari H, Hosaka M, Sudo S, Sakuragi N
Carcinogenesis 2014 Apr;35(4):760-8
Carcinogenesis 2014 Apr;35(4):760-8
Lack of correlation of stem cell markers in breast cancer stem cells.
Liu Y, Nenutil R, Appleyard MV, Murray K, Boylan M, Thompson AM, Coates PJ
British journal of cancer 2014 Apr 15;110(8):2063-71
British journal of cancer 2014 Apr 15;110(8):2063-71
ER, PR, HER2, Ki-67 and CK5 in Early and Late Relapsing Breast Cancer-Reduced CK5 Expression in Metastases.
Joensuu K, Leidenius M, Kero M, Andersson LC, Horwitz KB, Heikkilä P
Breast cancer : basic and clinical research 2013;7:23-34
Breast cancer : basic and clinical research 2013;7:23-34
An associated classification of triple negative breast cancer: the risk of relapse and the response to chemotherapy.
Zhang J, Wang Y, Yin Q, Zhang W, Zhang T, Niu Y
International journal of clinical and experimental pathology 2013;6(7):1380-91
International journal of clinical and experimental pathology 2013;6(7):1380-91
AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients.
Hrstka R, Brychtova V, Fabian P, Vojtesek B, Svoboda M
Disease markers 2013;35(4):207-12
Disease markers 2013;35(4):207-12
Biological and demographic profile of meningiomas in a cohort of Egyptian patients: impact on tumor recurrence.
Abdelzaher E, El Deeb NM, Gowil AG, Yehya A
TheScientificWorldJournal 2013;2013:375139
TheScientificWorldJournal 2013;2013:375139
Cyclooxygenase-2 169C>G and 8473T>C gene polymorphisms and prostaglandin E2 level in breast cancer: a case-control study.
Fawzy MS, Aly NM, Shalaby SM, El-Sawy WH, Abdul-Maksoud RS
Gene 2013 Sep 25;527(2):601-5
Gene 2013 Sep 25;527(2):601-5
Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration.
Gagnidze K, Weil ZM, Faustino LC, Schaafsma SM, Pfaff DW
Journal of neuroendocrinology 2013 Oct;25(10):939-55
Journal of neuroendocrinology 2013 Oct;25(10):939-55
The prognostic significance of metaplastic carcinoma of the breast (MCB)--a case controlled comparison study with infiltrating ductal carcinoma.
Lai HW, Tseng LM, Chang TW, Kuo YL, Hsieh CM, Chen ST, Kuo SJ, Su CC, Chen DR
Breast (Edinburgh, Scotland) 2013 Oct;22(5):968-73
Breast (Edinburgh, Scotland) 2013 Oct;22(5):968-73
The prognostic role of preoperative and (early) postoperatively change in CA15.3 serum levels in a single hospital cohort of primary operable breast cancers.
Brouckaert O, Laenen A, Wildiers H, Floris G, Moerman P, Van Limbergen E, Vergote I, Billen J, Christiaens MR, Neven P
Breast (Edinburgh, Scotland) 2013 Jun;22(3):254-62
Breast (Edinburgh, Scotland) 2013 Jun;22(3):254-62
Selective suppression of endothelial cytokine production by progesterone receptor.
Goddard LM, Ton AN, Org T, Mikkola HK, Iruela-Arispe ML
Vascular pharmacology 2013 Jul-Aug;59(1-2):36-43
Vascular pharmacology 2013 Jul-Aug;59(1-2):36-43
Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features.
Laliotis A, Vrekoussis T, Kafousi M, Sanidas E, Askoxilakis J, Melissas J, Mavroudis D, Castanas E, Stathopoulos EN
Breast (Edinburgh, Scotland) 2013 Feb;22(1):89-95
Breast (Edinburgh, Scotland) 2013 Feb;22(1):89-95
Quantification of ER/PR expression in ovarian low-grade serous carcinoma.
Escobar J, Klimowicz AC, Dean M, Chu P, Nation JG, Nelson GS, Ghatage P, Kalloger SE, Köbel M
Gynecologic oncology 2013 Feb;128(2):371-6
Gynecologic oncology 2013 Feb;128(2):371-6
TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression.
Bjerre C, Vinther L, Belling KC, Würtz SØ, Yadav R, Lademann U, Rigina O, Do KN, Ditzel HJ, Lykkesfeldt AE, Wang J, Nielsen HB, Brünner N, Gupta R, Schrohl AS, Stenvang J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Dec;34(6):3839-51
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2013 Dec;34(6):3839-51
Prognostic comparison of the proliferation markers (mitotic activity index, phosphohistone H3, Ki67), steroid receptors, HER2, high molecular weight cytokeratins and classical prognostic factors in T₁₋₂N₀M₀ breast cancer.
Gudlaugsson E, Klos J, Skaland I, Janssen EA, Smaaland R, Feng W, Shao Z, Malpica A, Baak JP
Polish journal of pathology : official journal of the Polish Society of Pathologists 2013 Apr;64(1):1-8
Polish journal of pathology : official journal of the Polish Society of Pathologists 2013 Apr;64(1):1-8
Prognostic comparison of the proliferation markers (mitotic activity index, phosphohistone H3, Ki67), steroid receptors, HER2, high molecular weight cytokeratins and classical prognostic factors in T₁₋₂N₀M₀ breast cancer.
Gudlaugsson E, Klos J, Skaland I, Janssen EA, Smaaland R, Feng W, Shao Z, Malpica A, Baak JP
Polish journal of pathology : official journal of the Polish Society of Pathologists 2013 Apr;64(1):1-8
Polish journal of pathology : official journal of the Polish Society of Pathologists 2013 Apr;64(1):1-8
Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature.
Marian C, Boila A, Soanca D, Malau M, Podeanu DM, Resetkova E, Stolnicu S
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2013 Apr;121(4):272-9
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2013 Apr;121(4):272-9
Pregnancy-related peritoneal ectopic decidua (deciduosis): morphological and clinical evaluation.
Bolat F, Canpolat T, Tarim E
Turk patoloji dergisi 2012;28(1):56-60
Turk patoloji dergisi 2012;28(1):56-60
Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review.
Hao JY, Yang CC, Liu FF, Yang YL, Li S, Li WD, Li YQ, Lang RG, Fan Y, Paulos E, Zhang XM, Fu L
Cancer biology & medicine 2012 Sep;9(3):197-201
Cancer biology & medicine 2012 Sep;9(3):197-201
Survival benefit of tamoxifen in estrogen receptor-negative and progesterone receptor-positive low grade breast cancer patients.
Yang LH, Tseng HS, Lin C, Chen LS, Chen ST, Kuo SJ, Chen DR
Journal of breast cancer 2012 Sep;15(3):288-95
Journal of breast cancer 2012 Sep;15(3):288-95
The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer.
Jonsdottir K, Zhang H, Jhagroe D, Skaland I, Slewa A, Björkblom B, Coffey ET, Gudlaugsson E, Smaaland R, Janssen EA, Baak JP
Breast cancer research and treatment 2012 Sep;135(2):381-90
Breast cancer research and treatment 2012 Sep;135(2):381-90
Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab.
Grell P, Fabian P, Khoylou M, Radova L, Slaby O, Hrstka R, Vyzula R, Hajduch M, Svoboda M
International journal of oncology 2012 Oct;41(4):1204-12
International journal of oncology 2012 Oct;41(4):1204-12
Applying the 2011 St Gallen panel of prognostic markers on a large single hospital cohort of consecutively treated primary operable breast cancers.
Brouckaert O, Laenen A, Vanderhaegen J, Wildiers H, Leunen K, Amant F, Berteloot P, Smeets A, Paridaens R, Christiaens MR, Floris G, Moerman P, Van Limbergen E, Peeters S, Weltens C, Vergote I, Neven P
Annals of oncology : official journal of the European Society for Medical Oncology 2012 Oct;23(10):2578-2584
Annals of oncology : official journal of the European Society for Medical Oncology 2012 Oct;23(10):2578-2584
Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients.
Makroo RN, Chowdhry M, Kumar M, Srivastava P, Tyagi R, Bhadauria P, Kaul S, Sarin R, Das PK, Dua H
Indian journal of pathology & microbiology 2012 Oct-Dec;55(4):481-4
Indian journal of pathology & microbiology 2012 Oct-Dec;55(4):481-4
Free circulating tumor DNA as a diagnostic marker for breast cancer.
Hashad D, Sorour A, Ghazal A, Talaat I
Journal of clinical laboratory analysis 2012 Nov;26(6):467-72
Journal of clinical laboratory analysis 2012 Nov;26(6):467-72
Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure.
Tergas AI, Buell-Gutbrod R, Gwin K, Kocherginsky M, Temkin SM, Fefferman A, Lengyel E, Yamada SD
Gynecologic oncology 2012 Nov;127(2):316-20
Gynecologic oncology 2012 Nov;127(2):316-20
A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin and trastuzumab for T2 breast cancers.
Lin C, Chen DR, Chang KJ, Chang TW, Wang HC
Cancer chemotherapy and pharmacology 2012 May;69(5):1363-8
Cancer chemotherapy and pharmacology 2012 May;69(5):1363-8
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
Masago K, Hosada W, Sasaki E, Murakami Y, Sugano M, Nagasaka T, Yamada M, Yatabe Y
Case reports in oncology 2012 May;5(2):471-8
Case reports in oncology 2012 May;5(2):471-8
A 10-year follow-up of triple-negative breast cancer patients in Taiwan.
Lin C, Chien SY, Kuo SJ, Chen LS, Chen ST, Lai HW, Chang TW, Chen DR
Japanese journal of clinical oncology 2012 Mar;42(3):161-7
Japanese journal of clinical oncology 2012 Mar;42(3):161-7
MiR-34b is associated with clinical outcome in triple-negative breast cancer patients.
Svoboda M, Sana J, Redova M, Navratil J, Palacova M, Fabian P, Slaby O, Vyzula R
Diagnostic pathology 2012 Mar 22;7:31
Diagnostic pathology 2012 Mar 22;7:31
Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases.
Yigit S, Pehlivan FS, Evcim G, Etit D
Pathology, research and practice 2012 Mar 15;208(3):147-50
Pathology, research and practice 2012 Mar 15;208(3):147-50
Investigation of immunohistochemical ERα, ERβ and ERβcx expressions in normal and neoplastic breast tissues.
Bozkurt KK, Kapucuoğlu N
Pathology, research and practice 2012 Mar 15;208(3):133-9
Pathology, research and practice 2012 Mar 15;208(3):133-9
Cytologic features of triple-negative breast carcinoma.
Bonzanini M, Morelli L, Bonandini EM, Leonardi E, Pertile R, Dalla Palma P
Cancer cytopathology 2012 Dec 25;120(6):401-9
Cancer cytopathology 2012 Dec 25;120(6):401-9
The pathologic characteristics of breast cancer in China and its shift during 1999-2008: a national-wide multicenter cross-sectional image over 10 years.
Zheng S, Bai JQ, Li J, Fan JH, Pang Y, Song QK, Huang R, Yang HJ, Xu F, Lu N, Qiao YL
International journal of cancer 2012 Dec 1;131(11):2622-31
International journal of cancer 2012 Dec 1;131(11):2622-31
Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report.
Haltas H, Bayrak R, Yenidunya S, Kosehan D, Sen M, Akin K
Diagnostic pathology 2012 Aug 6;7:91
Diagnostic pathology 2012 Aug 6;7:91
Stromal caveolin-1 expression in breast carcinoma. Correlation with early tumor recurrence and clinical outcome.
El-Gendi SM, Mostafa MF, El-Gendi AM
Pathology oncology research : POR 2012 Apr;18(2):459-69
Pathology oncology research : POR 2012 Apr;18(2):459-69
Wilms tumor-1, claudin-1 and ezrin are useful immunohistochemical markers that help to distinguish schwannoma from fibroblastic meningioma.
Singh A, Mishra AK, Ylaya K, Hewitt SM, Sharma KC, Saxena S
Pathology oncology research : POR 2012 Apr;18(2):383-9
Pathology oncology research : POR 2012 Apr;18(2):383-9
Clinical significance of KISS1 protein expression for brain invasion and metastasis.
Ulasov IV, Kaverina NV, Pytel P, Thaci B, Liu F, Hurst DR, Welch DR, Sattar HA, Olopade OI, Baryshnikov AY, Kadagidze ZG, Lesniak MS
Cancer 2012 Apr 15;118(8):2096-105
Cancer 2012 Apr 15;118(8):2096-105
Clinical and pathological features of breast cancer associated with the pathological complete response to anthracycline-based neoadjuvant chemotherapy.
Keskin S, Muslumanoglu M, Saip P, Karanlık H, Guveli M, Pehlivan E, Aydoğan F, Eralp Y, Aydıner A, Yavuz E, Ozmen V, Igci A, Topuz E
Oncology 2011;81(1):30-8
Oncology 2011;81(1):30-8
Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.
Heijmans J, Muncan V, Jacobs RJ, de Jonge-Muller ES, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR
PloS one 2011;6(7):e22620
PloS one 2011;6(7):e22620
Correlation of HER 2/neu gene amplification with immunohistochemistry and other prognostic factors in breast carcinoma.
Ramadan SS, Yapicier O, Kıhtır S, Erdemır A, Doğan TH, Uskent I, Onat H, Cakmakçi M
Turk patoloji dergisi 2011;27(3):196-203
Turk patoloji dergisi 2011;27(3):196-203
Overexpression of α-enolase correlates with poor survival in canine mammary carcinoma.
Chu PY, Hsu NC, Liao AT, Shih NY, Hou MF, Liu CH
BMC veterinary research 2011 Oct 21;7:62
BMC veterinary research 2011 Oct 21;7:62
Association between hormone receptor expression and epidermal growth factor receptor mutation in patients operated on for non-small cell lung cancer.
Sun HB, Zheng Y, Ou W, Fang Q, Li P, Ye X, Zhang BB, Yang H, Wang SY
The Annals of thoracic surgery 2011 May;91(5):1562-7
The Annals of thoracic surgery 2011 May;91(5):1562-7
May metaplastic breast carcinomas be actually basal-like carcinoma? Further evidence study with its ultrastructure and survival analysis.
Wang H, Guan B, Shi Q, Ma H, Zhou H, Wang X, Zhou X
Medical oncology (Northwood, London, England) 2011 Mar;28(1):42-50
Medical oncology (Northwood, London, England) 2011 Mar;28(1):42-50
Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
Meyer DS, Brinkhaus H, Müller U, Müller M, Cardiff RD, Bentires-Alj M
Cancer research 2011 Jul 1;71(13):4344-51
Cancer research 2011 Jul 1;71(13):4344-51
Prognostic significance of triple negative breast cancer at tumor size 1 cm and smaller.
Lai HW, Kuo SJ, Chen LS, Chi CW, Chen ST, Chang TW, Chen DR
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2011 Jan;37(1):18-24
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 2011 Jan;37(1):18-24
A case of prostatic adenocarcinoma with aberrant p63 expression: presentation with detailed immunohistochemical study and FISH analysis.
Baydar DE, Kulac I, Gurel B, De Marzo A
International journal of surgical pathology 2011 Feb;19(1):131-6
International journal of surgical pathology 2011 Feb;19(1):131-6
Ectopic endometrial tissue in mesonephric duct remnants in bitches.
Bartel C, Berghold P, Walter I
Reproduction in domestic animals = Zuchthygiene 2011 Dec;46(6):950-6
Reproduction in domestic animals = Zuchthygiene 2011 Dec;46(6):950-6
Correlation of histologic grade with other clinicopathological parameters, intrinsic subtype, and patients' clinical outcome in Taiwanese women.
Chen ST, Lai HW, Tseng HS, Chen LS, Kuo SJ, Chen DR
Japanese journal of clinical oncology 2011 Dec;41(12):1327-35
Japanese journal of clinical oncology 2011 Dec;41(12):1327-35
Recurrence of benign meningiomas: predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression.
Abdelzaher E, El-Gendi SM, Yehya A, Gowil AG
British journal of neurosurgery 2011 Dec;25(6):707-13
British journal of neurosurgery 2011 Dec;25(6):707-13
Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases.
Guan B, Wang H, Cao S, Rao Q, Wang Y, Zhu Y, Shi Q, Yin H, Wang X, Zhou X
Annals of diagnostic pathology 2011 Aug;15(4):225-32
Annals of diagnostic pathology 2011 Aug;15(4):225-32
Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors.
Giordano G, Lombardi M, Brigati F, Mancini C, Silini EM
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Sep;29(5):459-67
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Sep;29(5):459-67
p16INK4a expression in basal-like breast carcinoma.
Bohn OL, Fuertes-Camilo M, Navarro L, Saldivar J, Sanchez-Sosa S
International journal of clinical and experimental pathology 2010 Jun 30;3(6):600-7
International journal of clinical and experimental pathology 2010 Jun 30;3(6):600-7
Pseudo-placentational endometrial cysts in a bitch.
Bartel C, Schönkypl S, Walter I
Anatomia, histologia, embryologia 2010 Feb;39(1):74-80
Anatomia, histologia, embryologia 2010 Feb;39(1):74-80
Papillary apocrine metaplasia and columnar cell lesion with atypia: is there a shared common pathway?
Kosemehmetoglu K, Guler G
Annals of diagnostic pathology 2010 Dec;14(6):425-31
Annals of diagnostic pathology 2010 Dec;14(6):425-31
Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients.
Søiland H, Skaland I, Varhaug JE, Kørner H, Janssen EA, Gudlaugsson E, Baak JP, Søreide JA
Acta oncologica (Stockholm, Sweden) 2009;48(4):514-21
Acta oncologica (Stockholm, Sweden) 2009;48(4):514-21
Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs).
Locati LD, Perrone F, Losa M, Mela M, Casieri P, Orsenigo M, Cortelazzi B, Negri T, Tamborini E, Quattrone P, Bossi P, Rinaldi G, Bergamini C, Calderone RG, Liberatoscioli C, Licitra L
Oral oncology 2009 Nov;45(11):986-90
Oral oncology 2009 Nov;45(11):986-90
Triple negative breast carcinoma is a prognostic factor in Taiwanese women.
Lin C, Chien SY, Chen LS, Kuo SJ, Chang TW, Chen DR
BMC cancer 2009 Jun 18;9:192
BMC cancer 2009 Jun 18;9:192
Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive.
Van Calster B, Vanden Bempt I, Drijkoningen M, Pochet N, Cheng J, Van Huffel S, Hendrickx W, Decock J, Huang HJ, Leunen K, Amant F, Berteloot P, Paridaens R, Wildiers H, Van Limbergen E, Weltens C, Timmerman D, Van Gorp T, Smeets A, Van den Bogaert W, Vergote I, Christiaens MR, Neven P
Breast cancer research and treatment 2009 Jan;113(1):181-7
Breast cancer research and treatment 2009 Jan;113(1):181-7
A three-dimensional culture model of canine uterine glands.
Stadler K, Handler J, Schoenkypl S, Walter I
In vitro cellular & developmental biology. Animal 2009 Jan-Feb;45(1-2):35-43
In vitro cellular & developmental biology. Animal 2009 Jan-Feb;45(1-2):35-43
Identification of CD44v6(+)/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies.
Snyder EL, Bailey D, Shipitsin M, Polyak K, Loda M
Laboratory investigation; a journal of technical methods and pathology 2009 Aug;89(8):857-66
Laboratory investigation; a journal of technical methods and pathology 2009 Aug;89(8):857-66
Rabbit monoclonal antibodies show higher sensitivity than mouse monoclonals for estrogen and progesterone receptor evaluation in breast cancer by immunohistochemistry.
Rocha R, Nunes C, Rocha G, Oliveira F, Sanches F, Gobbi H
Pathology, research and practice 2008;204(9):655-62
Pathology, research and practice 2008;204(9):655-62
Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer.
Neven P, Van Calster B, Van den Bempt I, Van Huffel S, Van Belle V, Hendrickx W, Decock J, Wildiers H, Paridaens R, Amant F, Leunen K, Berteloot P, Timmerman D, Van Limbergen E, Weltens C, Van den Bogaert W, Smeets A, Vergote I, Christiaens MR, Drijkoningen M
Breast cancer research and treatment 2008 Jul;110(1):153-9
Breast cancer research and treatment 2008 Jul;110(1):153-9
Prognostic relevance of androgen receptor detection in operable breast cancer.
Søiland H, Kørner H, Skaland I, Janssen EA, Gudlaugsson E, Varhaug JE, Baak JP, Søreide JA
Journal of surgical oncology 2008 Dec 1;98(7):551-8
Journal of surgical oncology 2008 Dec 1;98(7):551-8
Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts.
Horwitz KB, Dye WW, Harrell JC, Kabos P, Sartorius CA
Proceedings of the National Academy of Sciences of the United States of America 2008 Apr 15;105(15):5774-9
Proceedings of the National Academy of Sciences of the United States of America 2008 Apr 15;105(15):5774-9
Expression of c-kit proto-oncogene product in breast cancer tissues.
Eroğlu A, Sari A
Medical oncology (Northwood, London, England) 2007;24(2):169-74
Medical oncology (Northwood, London, England) 2007;24(2):169-74
Expression of c-kit proto-oncogene product in breast cancer tissues.
Eroğlu A, Sari A
Medical oncology (Northwood, London, England) 2007;24(2):169-74
Medical oncology (Northwood, London, England) 2007;24(2):169-74
Matrix metalloproteinase expression patterns in luminal A type breast carcinomas.
Decock J, Hendrickx W, Drijkoningen M, Wildiers H, Neven P, Smeets A, Paridaens R
Disease markers 2007;23(3):189-96
Disease markers 2007;23(3):189-96
Matrix metalloproteinase expression patterns in luminal A type breast carcinomas.
Decock J, Hendrickx W, Drijkoningen M, Wildiers H, Neven P, Smeets A, Paridaens R
Disease markers 2007;23(3):189-96
Disease markers 2007;23(3):189-96
Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature.
Giordano G, D'Adda T, Gnetti L, Merisio C, Raboni S
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Jul;26(3):298-304
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Jul;26(3):298-304
Prognostic factors in Hungarian breast cancer patients.
Nádasi E, Anga B, Sándor J, Megyesi J, Kelemen D, Mottolese M, Natali PG, Hegedus G, Arany I, Ember I
Anticancer research 2007 Jan-Feb;27(1A):279-82
Anticancer research 2007 Jan-Feb;27(1A):279-82
A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer.
Rasmussen LM, Zaveri NT, Stenvang J, Peters RH, Lykkesfeldt AE
Breast cancer research and treatment 2007 Dec;106(2):191-203
Breast cancer research and treatment 2007 Dec;106(2):191-203
Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study.
Giordano G, D'Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Apr;26(2):199-204
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2007 Apr;26(2):199-204
Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient.
Sabah M, Mohan P, Kay E
Virchows Archiv : an international journal of pathology 2006 Oct;449(4):489-92
Virchows Archiv : an international journal of pathology 2006 Oct;449(4):489-92
Primary squamous cell carcinoma of the endometrium: a case report with immunohistochemical and molecular study.
Giordano G, D'Adda T, Merisio C, Gnetti L
Gynecologic oncology 2005 Mar;96(3):876-9
Gynecologic oncology 2005 Mar;96(3):876-9
Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line.
Sonne-Hansen K, Lykkesfeldt AE
The Journal of steroid biochemistry and molecular biology 2005 Jan;93(1):25-34
The Journal of steroid biochemistry and molecular biology 2005 Jan;93(1):25-34
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot was performed using Anti-Progesterone Receptor Monoclonal Antibody (Product # MA5-16393) and a ~110 kDa and ~82 kDa band corresponding to Progesterone Receptor was observed in T-47D and uterus tissue. Additional un-characterized bands (*) were also observed. Whole cell extracts (30ug lysate) of T-47D (Lane 1), SK-BR-3 (Lane 2), Mouse Lung (Lane 3), Rat Lung (Lane 4), Mouse Uterus (Lane 5) and Rat Uterus (Lane 6) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:2000 dilution) and detected by chemiluminescence with Goat anti-Rabbit IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A27036, 1:4000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005).
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunofluorescence analysis of Progesterone Receptor was performed using 70% confluent log phase T-47D cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Progesterone Receptor Monoclonal Antibody (Product # MA5-16393) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then with Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32731) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing nuclear localization. Panel e represents SK-BR-3 cells having no expression of Progesterone Receptor. Panel f represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemical analysis of Progesterone Receptor using anti-Progesterone Receptor Monoclonal Antibody (Product # MA5-16393) in Breast Carcinoma Cancer Tissue. The recommened dilution for this antibody in immunohistochemistry applications is 1:400.
