Explore
Validate
Learn
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [78]
- Comments [0]
- Validations
- Western blot [1]
- Blocking/Neutralizing [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MAB421-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-17/IL-17A Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects mouse IL-17 in direct ELISAs and Western blots. In direct ELISAs, 100% reactivity with recombinant rat IL-17A and approximately 40% reactivity with recombinant mouse (rm) IL-17A/IL-17F heterodimer is observed. No cross-reactivity with recombinant human IL-17, recombinant canine IL-17, rmIL-17B, rmIL-17C, rmIL-17D, rmIL-17E, or rmIL-17F is observed.
- Reactivity
- Mouse
- Host
- Rat
- Conjugate
- Unconjugated
- Antigen sequence
Q62386- Isotype
- IgG
- Antibody clone number
- 50104
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Endogenous IL-17A mediated neutrophil infiltration by promoting chemokines expression during chlamydial lung infection.
Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.
Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin-17A Which Downregulates E-Cadherin.
IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection.
IL-35 induces N2 phenotype of neutrophils to promote tumor growth.
Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γ.
Galectin-1-Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial Immunity.
IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity.
IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection.
IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling.
Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response.
Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway.
IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP).
Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A.
Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells.
Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice.
γδ T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFα.
Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.
Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites.
CD8 T cells regulate allergic contact dermatitis by modulating CCR2-dependent TNF/iNOS-expressing Ly6C+ CD11b+ monocytic cells.
Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases.
IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-γ-activated macrophage programming.
Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis.
Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.
Transcription factors GATA-3 and RORγt are important for determining the phenotype of allergic airway inflammation in a murine model of asthma.
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells.
TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy.
Lack of TNFR p55 results in heightened expression of IFN-γ and IL-17 during the development of reactive arthritis.
Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis.
Th17 immune responses contribute to the pathophysiology of aplastic anemia.
A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice.
IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.
IL-22 defines a novel immune pathway of antifungal resistance.
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.
Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.
Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function.
Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells.
Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis.
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.
Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice.
CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice.
Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity.
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease.
IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17.
IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.
Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response.
T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.
Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi.
Qiao S, Zhang H, Zha X, Niu W, Liang J, Pang G, Tang Y, Liu T, Zhao H, Wang Y, Bai H
Microbial pathogenesis 2019 Apr;129:106-111
Microbial pathogenesis 2019 Apr;129:106-111
Galectin-9 Is Critical for Mucosal Adaptive Immunity through the T Helper 17-IgA Axis.
Liang CC, Li CS, Weng IC, Chen HY, Lu HH, Huang CC, Liu FT
The American journal of pathology 2018 May;188(5):1225-1235
The American journal of pathology 2018 May;188(5):1225-1235
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, Yoo SM, Lee HS, Kang HC, Lee JY, Lee WS, Lee HJ, Kim EK, Jhun JY, Cho ML, Min JK, Cho YY
Cell death & disease 2018 Mar 14;9(3):401
Cell death & disease 2018 Mar 14;9(3):401
B Cells Produce the Tissue-Protective Protein RELMα during Helminth Infection, which Inhibits IL-17 Expression and Limits Emphysema.
Chen F, Wu W, Jin L, Millman A, Palma M, El-Naccache DW, Lothstein KE, Dong C, Edelblum KL, Gause WC
Cell reports 2018 Dec 4;25(10):2775-2783.e3
Cell reports 2018 Dec 4;25(10):2775-2783.e3
Estrogen Deficiency Promotes Cerebral Aneurysm Rupture by Upregulation of Th17 Cells and Interleukin-17A Which Downregulates E-Cadherin.
Hoh BL, Rojas K, Lin L, Fazal HZ, Hourani S, Nowicki KW, Schneider MB, Hosaka K
Journal of the American Heart Association 2018 Apr 13;7(8)
Journal of the American Heart Association 2018 Apr 13;7(8)
IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection.
Garth JM, Reeder KM, Godwin MS, Mackel JJ, Dunaway CW, Blackburn JP, Steele C
Journal of immunology (Baltimore, Md. : 1950) 2017 Sep 15;199(6):2140-2148
Journal of immunology (Baltimore, Md. : 1950) 2017 Sep 15;199(6):2140-2148
IL-35 induces N2 phenotype of neutrophils to promote tumor growth.
Zou JM, Qin J, Li YC, Wang Y, Li D, Shu Y, Luo C, Wang SS, Chi G, Guo F, Zhang GM, Feng ZH
Oncotarget 2017 May 16;8(20):33501-33514
Oncotarget 2017 May 16;8(20):33501-33514
Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-γ.
Okuyama H, Tominaga A, Fukuoka S, Taguchi T, Kusumoto Y, Ono S
Oncology reports 2017 Feb;37(2):684-694
Oncology reports 2017 Feb;37(2):684-694
Galectin-1-Driven Tolerogenic Programs Aggravate Yersinia enterocolitica Infection by Repressing Antibacterial Immunity.
Davicino RC, Méndez-Huergo SP, Eliçabe RJ, Stupirski JC, Autenrieth I, Di Genaro MS, Rabinovich GA
Journal of immunology (Baltimore, Md. : 1950) 2017 Aug 15;199(4):1382-1392
Journal of immunology (Baltimore, Md. : 1950) 2017 Aug 15;199(4):1382-1392
IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity.
Subbarayal B, Chauhan SK, Di Zazzo A, Dana R
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 1;197(9):3464-3470
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 1;197(9):3464-3470
IL-17A Is an Important Effector of the Immune Response of the Mammary Gland to Escherichia coli Infection.
Porcherie A, Gilbert FB, Germon P, Cunha P, Trotereau A, Rossignol C, Winter N, Berthon P, Rainard P
Journal of immunology (Baltimore, Md. : 1950) 2016 Jan 15;196(2):803-12
Journal of immunology (Baltimore, Md. : 1950) 2016 Jan 15;196(2):803-12
IL-17A exacerbates diabetic retinopathy by impairing Müller cell function via Act1 signaling.
Qiu AW, Bian Z, Mao PA, Liu QH
Experimental & molecular medicine 2016 Dec 16;48(12):e280
Experimental & molecular medicine 2016 Dec 16;48(12):e280
Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response.
Quirino GFS, Nascimento MSL, Davoli-Ferreira M, Sacramento LA, Lima MHF, Almeida RP, Carregaro V, Silva JS
Infection and immunity 2016 Aug;84(8):2289-2298
Infection and immunity 2016 Aug;84(8):2289-2298
Seminal plasma induces inflammation in the uterus through the γδ T/IL-17 pathway.
Song ZH, Li ZY, Li DD, Fang WN, Liu HY, Yang DD, Meng CY, Yang Y, Peng JP
Scientific reports 2016 Apr 25;6:25118
Scientific reports 2016 Apr 25;6:25118
IL17 Mediates Pelvic Pain in Experimental Autoimmune Prostatitis (EAP).
Murphy SF, Schaeffer AJ, Done J, Wong L, Bell-Cohn A, Roman K, Cashy J, Ohlhausen M, Thumbikat P
PloS one 2015;10(5):e0125623
PloS one 2015;10(5):e0125623
Neonatal Streptococcus pneumoniae infection may aggravate adulthood allergic airways disease in association with IL-17A.
Yang B, Liu R, Yang T, Jiang X, Zhang L, Wang L, Wang Q, Luo Z, Liu E, Fu Z
PloS one 2015;10(3):e0123010
PloS one 2015;10(3):e0123010
Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells.
Kim YU, Lim H, Jung HE, Wetsel RA, Chung Y
PloS one 2015;10(3):e0120294
PloS one 2015;10(3):e0120294
Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa NT
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5407-16
Journal of immunology (Baltimore, Md. : 1950) 2015 Jun 1;194(11):5407-16
Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice.
Qi H, Yang H, Xu G, Ren J, Hua W, Shi Y, Torsvik M, Florholmen J, Cui G
Immunobiology 2015 Jan;220(1):54-9
Immunobiology 2015 Jan;220(1):54-9
γδ T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFα.
Mathews JA, Williams AS, Brand JD, Wurmbrand AP, Chen L, Ninin FM, Si H, Kasahara DI, Shore SA
PloS one 2014;9(5):e97707
PloS one 2014;9(5):e97707
Leukocyte attraction by CCL20 and its receptor CCR6 in humans and mice with pneumococcal meningitis.
Klein M, Brouwer MC, Angele B, Geldhoff M, Marquez G, Varona R, Häcker G, Schmetzer H, Häcker H, Hammerschmidt S, van der Ende A, Pfister HW, van de Beek D, Koedel U
PloS one 2014;9(4):e93057
PloS one 2014;9(4):e93057
Systemic inflammatory response elicited by superantigen destabilizes T regulatory cells, rendering them ineffective during toxic shock syndrome.
Tilahun AY, Chowdhary VR, David CS, Rajagopalan G
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2919-30
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2919-30
Porphyromonas gingivalis-derived lysine gingipain enhances osteoclast differentiation induced by tumor necrosis factor-α and interleukin-1β but suppresses that by interleukin-17A: importance of proteolytic degradation of osteoprotegerin by lysine gingipain.
Akiyama T, Miyamoto Y, Yoshimura K, Yamada A, Takami M, Suzawa T, Hoshino M, Imamura T, Akiyama C, Yasuhara R, Mishima K, Maruyama T, Kohda C, Tanaka K, Potempa J, Yasuda H, Baba K, Kamijo R
The Journal of biological chemistry 2014 May 30;289(22):15621-30
The Journal of biological chemistry 2014 May 30;289(22):15621-30
IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites.
Bonnegarde-Bernard A, Jee J, Fial MJ, Aeffner F, Cormet-Boyaka E, Davis IC, Lin M, Tomé D, Karin M, Sun Y, Boyaka PN
Mucosal immunology 2014 Mar;7(2):257-67
Mucosal immunology 2014 Mar;7(2):257-67
CD8 T cells regulate allergic contact dermatitis by modulating CCR2-dependent TNF/iNOS-expressing Ly6C+ CD11b+ monocytic cells.
Chong SZ, Tan KW, Wong FHS, Chua YL, Tang Y, Ng LG, Angeli V, Kemeny DM
The Journal of investigative dermatology 2014 Mar;134(3):666-676
The Journal of investigative dermatology 2014 Mar;134(3):666-676
Interleukin-17A modulates circulating tumor cells in tumor draining vein of colorectal cancers and affects metastases.
Tseng JY, Yang CY, Liang SC, Liu RS, Yang SH, Lin JK, Chen YM, Wu YC, Jiang JK, Lin CH
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jun 1;20(11):2885-97
Clinical cancer research : an official journal of the American Association for Cancer Research 2014 Jun 1;20(11):2885-97
IL-17A produced by neutrophils protects against pneumonic plague through orchestrating IFN-γ-activated macrophage programming.
Bi Y, Zhou J, Yang H, Wang X, Zhang X, Wang Q, Wu X, Han Y, Song Y, Tan Y, Du Z, Yang H, Zhou D, Cui Y, Zhou L, Yan Y, Zhang P, Guo Z, Wang X, Liu G, Yang R
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):704-13
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):704-13
Involvement of IL-9 in Th17-associated inflammation and angiogenesis of psoriasis.
Singh TP, Schön MP, Wallbrecht K, Gruber-Wackernagel A, Wang XJ, Wolf P
PloS one 2013;8(1):e51752
PloS one 2013;8(1):e51752
Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis.
Hou L, Jie Z, Desai M, Liang Y, Soong L, Wang T, Sun J
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 15;190(2):621-9
Journal of immunology (Baltimore, Md. : 1950) 2013 Jan 15;190(2):621-9
Transcription factors GATA-3 and RORγt are important for determining the phenotype of allergic airway inflammation in a murine model of asthma.
Ano S, Morishima Y, Ishii Y, Yoh K, Yageta Y, Ohtsuka S, Matsuyama M, Kawaguchi M, Takahashi S, Hizawa N
Journal of immunology (Baltimore, Md. : 1950) 2013 Feb 1;190(3):1056-65
Journal of immunology (Baltimore, Md. : 1950) 2013 Feb 1;190(3):1056-65
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Wu SY, Yu JS, Liu FT, Miaw SC, Wu-Hsieh BA
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3427-37
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3427-37
Salmonella enterica induces joint inflammation and expression of interleukin-17 in draining lymph nodes early after onset of enterocolitis in mice.
Noto Llana M, Sarnacki SH, Vázquez MV, Gartner AS, Giacomodonato MN, Cerquetti MC
Infection and immunity 2012 Jun;80(6):2231-9
Infection and immunity 2012 Jun;80(6):2231-9
Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells.
Park SY, Gupta D, Kim CH, Dziarski R
PloS one 2011;6(9):e24961
PloS one 2011;6(9):e24961
TLR2-mediated production of IL-27 and chemokines by respiratory epithelial cells promotes bleomycin-induced pulmonary fibrosis in mice.
Kim HS, Go H, Akira S, Chung DH
Journal of immunology (Baltimore, Md. : 1950) 2011 Oct 15;187(8):4007-17
Journal of immunology (Baltimore, Md. : 1950) 2011 Oct 15;187(8):4007-17
IL-23 is required for long-term control of Mycobacterium tuberculosis and B cell follicle formation in the infected lung.
Khader SA, Guglani L, Rangel-Moreno J, Gopal R, Junecko BA, Fountain JJ, Martino C, Pearl JE, Tighe M, Lin YY, Slight S, Kolls JK, Reinhart TA, Randall TD, Cooper AM
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 15;187(10):5402-7
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 15;187(10):5402-7
Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy.
Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesnière A, Ibrahim N, Déchanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L
The Journal of experimental medicine 2011 Mar 14;208(3):491-503
The Journal of experimental medicine 2011 Mar 14;208(3):491-503
Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy.
Shen H, Harris G, Chen W, Sjostedt A, Ryden P, Conlan W
PloS one 2010 Oct 12;5(10):e13349
PloS one 2010 Oct 12;5(10):e13349
Lack of TNFR p55 results in heightened expression of IFN-γ and IL-17 during the development of reactive arthritis.
Eliçabe RJ, Cargnelutti E, Serer MI, Stege PW, Valdez SR, Toscano MA, Rabinovich GA, Di Genaro MS
Journal of immunology (Baltimore, Md. : 1950) 2010 Oct 1;185(7):4485-95
Journal of immunology (Baltimore, Md. : 1950) 2010 Oct 1;185(7):4485-95
Protective role of interleukin-17 in murine NKT cell-driven acute experimental hepatitis.
Wondimu Z, Santodomingo-Garzon T, Le T, Swain MG
The American journal of pathology 2010 Nov;177(5):2334-46
The American journal of pathology 2010 Nov;177(5):2334-46
Th17 immune responses contribute to the pathophysiology of aplastic anemia.
de Latour RP, Visconte V, Takaku T, Wu C, Erie AJ, Sarcon AK, Desierto MJ, Scheinberg P, Keyvanfar K, Nunez O, Chen J, Young NS
Blood 2010 Nov 18;116(20):4175-84
Blood 2010 Nov 18;116(20):4175-84
A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice.
Gao Q, Jiang Y, Ma T, Zhu F, Gao F, Zhang P, Guo C, Wang Q, Wang X, Ma C, Zhang Y, Chen W, Zhang L
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 15;185(10):5820-7
Journal of immunology (Baltimore, Md. : 1950) 2010 Nov 15;185(10):5820-7
IL-17A-producing gammadelta T and Th17 lymphocytes mediate lung inflammation but not fibrosis in experimental silicosis.
Lo Re S, Dumoutier L, Couillin I, Van Vyve C, Yakoub Y, Uwambayinema F, Marien B, van den Brûle S, Van Snick J, Uyttenhove C, Ryffel B, Renauld JC, Lison D, Huaux F
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 1;184(11):6367-77
Journal of immunology (Baltimore, Md. : 1950) 2010 Jun 1;184(11):6367-77
IL-22 defines a novel immune pathway of antifungal resistance.
De Luca A, Zelante T, D'Angelo C, Zagarella S, Fallarino F, Spreca A, Iannitti RG, Bonifazi P, Renauld JC, Bistoni F, Puccetti P, Romani L
Mucosal immunology 2010 Jul;3(4):361-73
Mucosal immunology 2010 Jul;3(4):361-73
IL-17 produced by neutrophils regulates IFN-gamma-mediated neutrophil migration in mouse kidney ischemia-reperfusion injury.
Li L, Huang L, Vergis AL, Ye H, Bajwa A, Narayan V, Strieter RM, Rosin DL, Okusa MD
The Journal of clinical investigation 2010 Jan;120(1):331-42
The Journal of clinical investigation 2010 Jan;120(1):331-42
Interleukin-17-producing gammadelta+ T cells protect NOD mice from type 1 diabetes through a mechanism involving transforming growth factor-beta.
Han G, Wang R, Chen G, Wang J, Xu R, Wang L, Feng J, Li X, Guo R, Fu L, Shen B, Li Y
Immunology 2010 Feb;129(2):197-206
Immunology 2010 Feb;129(2):197-206
Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lung.
Redford PS, Boonstra A, Read S, Pitt J, Graham C, Stavropoulos E, Bancroft GJ, O'Garra A
European journal of immunology 2010 Aug;40(8):2200-10
European journal of immunology 2010 Aug;40(8):2200-10
Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis.
Cruz A, Fraga AG, Fountain JJ, Rangel-Moreno J, Torrado E, Saraiva M, Pereira DR, Randall TD, Pedrosa J, Cooper AM, Castro AG
The Journal of experimental medicine 2010 Aug 2;207(8):1609-16
The Journal of experimental medicine 2010 Aug 2;207(8):1609-16
Chlamydial respiratory infection during allergen sensitization drives neutrophilic allergic airways disease.
Horvat JC, Starkey MR, Kim RY, Beagley KW, Preston JA, Gibson PG, Foster PS, Hansbro PM
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 15;184(8):4159-69
Journal of immunology (Baltimore, Md. : 1950) 2010 Apr 15;184(8):4159-69
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.
Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL
Nature medicine 2009 Sep;15(9):1016-22
Nature medicine 2009 Sep;15(9):1016-22
Peroxisome proliferator-activated receptor gamma agonist down-regulates IL-17 expression in a murine model of allergic airway inflammation.
Park SJ, Lee KS, Kim SR, Min KH, Choe YH, Moon H, Chae HJ, Yoo WH, Lee YC
Journal of immunology (Baltimore, Md. : 1950) 2009 Sep 1;183(5):3259-67
Journal of immunology (Baltimore, Md. : 1950) 2009 Sep 1;183(5):3259-67
Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response.
Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 1;106(35):14954-9
Proceedings of the National Academy of Sciences of the United States of America 2009 Sep 1;106(35):14954-9
Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13.
He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS
The Journal of allergy and clinical immunology 2009 Oct;124(4):761-70.e1
The Journal of allergy and clinical immunology 2009 Oct;124(4):761-70.e1
IL-17/Th17 promotes type 1 T cell immunity against pulmonary intracellular bacterial infection through modulating dendritic cell function.
Bai H, Cheng J, Gao X, Joyee AG, Fan Y, Wang S, Jiao L, Yao Z, Yang X
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 1;183(9):5886-95
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 1;183(9):5886-95
Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells.
Tigno-Aranjuez JT, Jaini R, Tuohy VK, Lehmann PV, Tary-Lehmann M
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 1;183(9):5654-61
Journal of immunology (Baltimore, Md. : 1950) 2009 Nov 1;183(9):5654-61
Anti-inflammatory effects of IL-17A on Helicobacter pylori-induced gastritis.
Otani K, Watanabe T, Tanigawa T, Okazaki H, Yamagami H, Watanabe K, Tominaga K, Fujiwara Y, Oshitani N, Arakawa T
Biochemical and biophysical research communications 2009 May 1;382(2):252-8
Biochemical and biophysical research communications 2009 May 1;382(2):252-8
Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge.
Hamada H, Garcia-Hernandez Mde L, Reome JB, Misra SK, Strutt TM, McKinstry KK, Cooper AM, Swain SL, Dutton RW
Journal of immunology (Baltimore, Md. : 1950) 2009 Mar 15;182(6):3469-81
Journal of immunology (Baltimore, Md. : 1950) 2009 Mar 15;182(6):3469-81
Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells.
Yuan X, Ansari MJ, D'Addio F, Paez-Cortez J, Schmitt I, Donnarumma M, Boenisch O, Zhao X, Popoola J, Clarkson MR, Yagita H, Akiba H, Freeman GJ, Iacomini J, Turka LA, Glimcher LH, Sayegh MH
Proceedings of the National Academy of Sciences of the United States of America 2009 Jun 30;106(26):10734-9
Proceedings of the National Academy of Sciences of the United States of America 2009 Jun 30;106(26):10734-9
A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum.
Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton MT, Arulanandam B, Zhang J, Zhong G
Journal of immunology (Baltimore, Md. : 1950) 2009 Jul 15;183(2):1291-300
Journal of immunology (Baltimore, Md. : 1950) 2009 Jul 15;183(2):1291-300
Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression.
Chauhan SK, El Annan J, Ecoiffier T, Goyal S, Zhang Q, Saban DR, Dana R
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1247-52
Journal of immunology (Baltimore, Md. : 1950) 2009 Feb 1;182(3):1247-52
Interleukin-17 causes neutrophil mediated inflammation in ovalbumin-induced uveitis in DO11.10 mice.
Zhang Z, Zhong W, Spencer D, Chen H, Lu H, Kawaguchi T, Rosenbaum JT
Cytokine 2009 Apr;46(1):79-91
Cytokine 2009 Apr;46(1):79-91
CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice.
Burrell BE, Csencsits K, Lu G, Grabauskiene S, Bishop DK
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3906-14
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 15;181(6):3906-14
Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice.
Koenders MI, Devesa I, Marijnissen RJ, Abdollahi-Roodsaz S, Boots AM, Walgreen B, di Padova FE, Nicklin MJ, Joosten LA, van den Berg WB
Arthritis and rheumatism 2008 Nov;58(11):3461-70
Arthritis and rheumatism 2008 Nov;58(11):3461-70
Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.
Iwanami K, Matsumoto I, Tanaka-Watanabe Y, Inoue A, Mihara M, Ohsugi Y, Mamura M, Goto D, Ito S, Tsutsumi A, Kishimoto T, Sumida T
Arthritis and rheumatism 2008 Mar;58(3):754-63
Arthritis and rheumatism 2008 Mar;58(3):754-63
Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection.
Bozza S, Zelante T, Moretti S, Bonifazi P, DeLuca A, D'Angelo C, Giovannini G, Garlanda C, Boon L, Bistoni F, Puccetti P, Mantovani A, Romani L
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 15;180(6):4022-31
Journal of immunology (Baltimore, Md. : 1950) 2008 Mar 15;180(6):4022-31
A distinct subset of natural killer T cells produces IL-17, contributing to airway infiltration of neutrophils but not to airway hyperreactivity.
Lee KA, Kang MH, Lee YS, Kim YJ, Kim DH, Ko HJ, Kang CY
Cellular immunology 2008 Jan;251(1):50-5
Cellular immunology 2008 Jan;251(1):50-5
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease.
Romani L, Fallarino F, De Luca A, Montagnoli C, D'Angelo C, Zelante T, Vacca C, Bistoni F, Fioretti MC, Grohmann U, Segal BH, Puccetti P
Nature 2008 Jan 10;451(7175):211-5
Nature 2008 Jan 10;451(7175):211-5
Interferon-gamma regulates idiopathic pneumonia syndrome, a Th17+CD4+ T-cell-mediated graft-versus-host disease.
Mauermann N, Burian J, von Garnier C, Dirnhofer S, Germano D, Schuett C, Tamm M, Bingisser R, Eriksson U, Hunziker L
American journal of respiratory and critical care medicine 2008 Aug 15;178(4):379-88
American journal of respiratory and critical care medicine 2008 Aug 15;178(4):379-88
IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17.
Kohyama S, Ohno S, Isoda A, Moriya O, Belladonna ML, Hayashi H, Iwakura Y, Yoshimoto T, Akatsuka T, Matsui M
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3917-25
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3917-25
IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance.
Zelante T, De Luca A, Bonifazi P, Montagnoli C, Bozza S, Moretti S, Belladonna ML, Vacca C, Conte C, Mosci P, Bistoni F, Puccetti P, Kastelein RA, Kopf M, Romani L
European journal of immunology 2007 Oct;37(10):2695-706
European journal of immunology 2007 Oct;37(10):2695-706
Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge.
He R, Oyoshi MK, Jin H, Geha RS
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 2;104(40):15817-22
Proceedings of the National Academy of Sciences of the United States of America 2007 Oct 2;104(40):15817-22
Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity.
Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG
Journal of immunology (Baltimore, Md. : 1950) 2007 Oct 1;179(7):4313-7
Journal of immunology (Baltimore, Md. : 1950) 2007 Oct 1;179(7):4313-7
Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response.
Irmler IM, Gajda M, Bräuer R
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 1;179(9):6228-36
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov 1;179(9):6228-36
T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
The Journal of allergy and clinical immunology 2007 Mar;119(3):662-70
The Journal of allergy and clinical immunology 2007 Mar;119(3):662-70
Functional relevance of the IL-23-IL-17 axis in lungs in vivo.
Ivanov S, Bozinovski S, Bossios A, Valadi H, Vlahos R, Malmhäll C, Sjöstrand M, Kolls JK, Anderson GP, Lindén A
American journal of respiratory cell and molecular biology 2007 Apr;36(4):442-51
American journal of respiratory cell and molecular biology 2007 Apr;36(4):442-51
Resident Vdelta1+ gammadelta T cells control early infiltration of neutrophils after Escherichia coli infection via IL-17 production.
Shibata K, Yamada H, Hara H, Kishihara K, Yoshikai Y
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 1;178(7):4466-72
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 1;178(7):4466-72
Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation.
Sergejeva S, Ivanov S, Lötvall J, Lindén A
American journal of respiratory cell and molecular biology 2005 Sep;33(3):248-53
American journal of respiratory cell and molecular biology 2005 Sep;33(3):248-53
Endogenous IL-17 as a mediator of neutrophil recruitment caused by endotoxin exposure in mouse airways.
Miyamoto M, Prause O, Sjöstrand M, Laan M, Lötvall J, Lindén A
Journal of immunology (Baltimore, Md. : 1950) 2003 May 1;170(9):4665-72
Journal of immunology (Baltimore, Md. : 1950) 2003 May 1;170(9):4665-72
Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferi.
Burchill MA, Nardelli DT, England DM, DeCoster DJ, Christopherson JA, Callister SM, Schell RF
Infection and immunity 2003 Jun;71(6):3437-42
Infection and immunity 2003 Jun;71(6):3437-42
No comments: Submit comment
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of Recombinant Mouse IL-17/IL-17A by Western Blot. Western blot shows 25 ng of Recombinant Mouse IL-17/ IL-17A (Catalog # 421-ML), Recombinant Human IL-17/IL-17A (Catalog # 317-ILB), Recombinant Rat IL-17/IL-17A (Catalog # 8410-IL), and Recombinant Mouse IL-17F (Catalog # 2057-IL). PVDF Membrane was probed with 1 µg/mL of Rat Anti-Mouse IL-17/ IL-17A Monoclonal Antibody (Catalog # MAB421) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). A specific band was detected for IL-17/IL-17A at approximately 15 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.
Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- IL-6 Secretion Induced by IL-17 and Neutralization by Mouse IL-17 Antibody. Recombinant Mouse IL-17 (Catalog # 421-ML) stimulates IL-6 secretion in the NIH-3T3 mouse embryonic fibroblast cell line in a dose-dependent manner (orange line), as measured by the Mouse IL-6 Quantikine ELISA Kit (Catalog # M6000B). IL-6 secretion elicited by Recombinant Mouse IL-17 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL-17 Monoclonal Antibody (Catalog # MAB421). The ND50 is typically 0.05-0.15 µg/mL.
