NBP1-40894AF700

antibody from Novus Biologicals
Targeting: P2RX7 MGC20089, P2X7
Provider product page for NBP1-40894AF700
Immunocytochemistry
Flow cytometry

Antibody data

Product number
NBP1-40894AF700 - Provider product page
Provider
Novus Biologicals
Product name
Rat Monoclonal P2X7/P2RX7 Antibody
Antibody type
Monoclonal
Description
Protein G purified. This antibody recognises the P2X purinoceptor 7, also known as P2X7. The P2X7 ATP receptor has a distinctive long C-terminal tail with multiple potential protein and lipid interaction motifs and is highly polymorphic. It is a cation selective ion channel that opens up on binding of extracellular ATP. Sustained activation by extracellular ATP results in the formation of a reversible pore in the plasma membrane that is permeable to hydrophilic solutes of up to 900 Da. Once a pore is opened massive upset of cytoplasmic ion homeostasis occurs and the pore stays open as long as it is bound by ATP. Should ATP stimulation continue the cell will become irreversibly damaged and die. P2X7 plays a key role in the maturation and release of IL-1 and other IL-1 family members during inflammation. As such, P2X7 blockers might be useful as anti-inflammatory agents.
Reactivity
Mouse
Host
Rat
Conjugate
Near infrared dye
Isotype
IgG
Vial size
0.1 ml
Storage
Store at 4C in the dark.
P2RX7 protein structure - NBP1-40894AF700 shown in red.