Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Blocking/Neutralizing [1]
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- Product number
- AF-418-NA - Provider product page
- Provider
- R&D Systems
- Product name
- Mouse IL-11 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse IL-11 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant human IL-11 is observed.
- Reactivity
- Mouse
- Host
- Goat
- Conjugate
- Unconjugated
- Antigen sequence
P47873
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
Archives of dermatological research 2001 Nov;293(10):508-14
Archives of dermatological research 2001 Nov;293(10):508-14
The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice.
Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M
Archives of dermatological research 2001 Nov;293(10):508-14
Archives of dermatological research 2001 Nov;293(10):508-14
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Supportive validation
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- R&D Systems (provider)
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- Experimental details
- Cell Proliferation Induced by IL-11 and Neutralization by Mouse IL-11 Antibody. Recombinant Mouse IL-11 (Catalog # 418-ML) stimulates proliferation in the T11 mouse plasmacytoma cell line in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-11 (0.75 ng/mL) is neutralized (green line) by increasing concentrations of Mouse IL-11 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-418-NA). The ND50 is typically 8-50 ng/mL.