Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- orb97037 - Provider product page
- Provider
- Biorbyt
- Product name
- DLL1 antibody
- Antibody type
- Polyclonal
- Description
- Rabbit Polyclonal to DLL1. DLL1(DELTA-LIKE 1) also known as DL1 or DELTA1, is a protein that in humans is encoded by the DLL1 gene. DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. Using FISH, Gray et al. (1999) mapped the DLL1 gene to chromosome 6q27, near a locus for type I diabetes. Functional analysis by Han et al. (2000) suggested that a soluble fusion protein containing the DSL domain of DLL1 and its adjacent 50 N-terminal amino acids increased the viability of hemopoietic cells but inhibited cell death. Jaleco et al. (2001) used a cell coculture assay to show that DLL1 blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. In contrast, JAG1 did not disturb either B-cell or T-cell/NK-cell development. Galceran et al. found that mouse Lef1 bound multiple sites in the Dll1 promoter in vitro and in vivo, and mutation of the Lef1 sites impaired expression of a reporter transgene in the presomitic mesoderm of embryonic mice.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 100 μg
- Concentration
- 0.1-0.5 μg/ml
- Storage
- Store at -20°C for one year.After reconstitution, at 4°C. for one month. It can also be aliquotted and stored frozen at -20°C. for a longer time.Avoid repeated freezing and thawing.
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Supportive validation
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- Biorbyt (provider)
- Main image
- Experimental details
- Western blot analysis of Lane 1: Recombinant Human DLL1 Protein 10ng, Lane 2: Recombinant Human DLL1 Protein 5ng, Lane 3: Recombinant Human DLL1 Protein 2.5ng, Lane 4: Recombinant Human DLL1 Protein 1.25ng using DLL1 antibody