Explore
Validate
Learn
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Flow cytometry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 25-5899-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- FceR1 alpha Monoclonal Antibody (AER-37 (CRA1)), PE-Cyanine7, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The AER-37 monoclonal antibody reacts with the Fc epsilon RI alpha subunit, an IgE-binding subunit lacking signal-transducing ability. Fc epsilon RI apha is expressed on mast and basophil cells and is upregulated by the presence of IgE. Fc epsilon RI alpha forms a tetrameric complex with one beta and two gamma subunits. The beta and gamma subunits possess immunoreceptor tyrosine-based activation motifs (ITAM). The Fc epsilon RI complex plays an important role in triggering IgE-mediated allergic reactions.
- Antibody clone number
- AER-37 (CRA1)
- Concentration
- 5 µL/Test
Submitted references Human mast cells promote colon cancer growth via bidirectional crosstalk: studies in 2D and 3D coculture models.
Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.
IgE- and FcepsilonRI-mediated migration of human basophils.
IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release.
Yu Y, Blokhuis B, Derks Y, Kumari S, Garssen J, Redegeld F
Oncoimmunology 2018;7(11):e1504729
Oncoimmunology 2018;7(11):e1504729
Dendritic cell-bound IgE functions to restrain allergic inflammation at mucosal sites.
Platzer B, Baker K, Vera MP, Singer K, Panduro M, Lexmond WS, Turner D, Vargas SO, Kinet JP, Maurer D, Baron RM, Blumberg RS, Fiebiger E
Mucosal immunology 2015 May;8(3):516-32
Mucosal immunology 2015 May;8(3):516-32
IgE- and FcepsilonRI-mediated migration of human basophils.
Suzukawa M, Hirai K, Iikura M, Nagase H, Komiya A, Yoshimura-Uchiyama C, Yamada H, Ra C, Ohta K, Yamamoto K, Yamaguchi M
International immunology 2005 Sep;17(9):1249-55
International immunology 2005 Sep;17(9):1249-55
IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release.
Yamaguchi M, Sayama K, Yano K, Lantz CS, Noben-Trauth N, Ra C, Costa JJ, Galli SJ
Journal of immunology (Baltimore, Md. : 1950) 1999 May 1;162(9):5455-65
Journal of immunology (Baltimore, Md. : 1950) 1999 May 1;162(9):5455-65
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with Anti-Human IgE PE (Product # 12-6986-42) and Mouse IgG2b K Isotype Control PE-Cyanine7 (Product # 25-4732-81) (left) or Anti-Human Fc epsilon Receptor I alpha (FceR1) PE-Cyanine7 (right). Cells in the lymphocyte gate were used for analysis (note: basophils reside in FSC/SSC position of lymphocytes).
