334614

antibody from BioLegend

Targeting: FCER1A FCE1A

Antibody data

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Validation data

Product number: 334614 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#334614, RRID:AB_2168080
Product name: Alexa Fluor® 647 anti-human FcåRIá [AER-37 (CRA-1)]
Antibody type: Monoclonal
Antigen: FceRIa
Description: High affinity IgE receptor (FcεRI) plays a key role in IgE-mediated allergic immune response. FcεRI is a tetrameric receptor complex, which is composed of one α-subunit (FcεRIα), one β-subunit, and two γ-subunits. FcεRIα directly binds IgE with high affinity, while the β- and γ-chains are responsible for mediating intracellular signals. FcεRIα is a 50 kD transmembrane protein with Ig superfamily structure. It is primarily found on mast cells and basophils. Further studies have indicated that FcεRIα is also expressed on many inflammatory cells including cutaneuos Langerhans cells, dendritic cells, monocytes of patients with allergic disorders, platelets, bronchial epithelial cells, eosinophils produced in hypereosinophilic syndrome, and neutrophils from allergy-induced asthma patients.
Reactivity: Human
Host: Mouse
Conjugate: Red dye
Isotype: IgG
Vial size: 100 tests
Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

FCER1A protein structure - 334614 shown in red.