NBP2-47996PEATT594

antibody from Novus Biologicals

Targeting: ALPL HOPS, TNALP, TNAP, TNSALP

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NBP2-47996PEATT594

Provider

Novus Biologicals

Product name

Mouse Monoclonal Alkaline Phosphatase, Tissue Non-Specific Antibody

Antibody type

Monoclonal

Description

Protein A or G purified. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypo-phosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.

Reactivity

Human, Simian

Host

Mouse

Conjugate

Red dye

Isotype

IgG

Vial size

0.1 ml

Storage

Store at 4C in the dark. Do not freeze.