orb169713

antibody from Biorbyt

Targeting: EGLN1 C1orf12, HIFPH2, PHD2, SM-20, ZMYND6

No application information provided.

Antibody Data

Product number

orb169713

Provider

Biorbyt

Product name

Anti-EGLN1 antibody

Antibody type

Monoclonal

Description

Mouse Monoclonal antibody to EGLN1.EGLN1 catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex which has a vital role in mammalian oxygen homeostasis. PHD1 (Egln2), PHD-2 (Egln1), and PHD3 (Egln3) belong to the Egln family of proline hydroxylases. The EGLN family that is known to be a cellular oxygen sensor initiates the first step of HIF degradation through the VHL/ubiquitin pathway. PHD1 and PHD2 hydroxylate both proline 402 and proline 564, however PHD3 can only hydroxylate proline 564. Other than HIF, PHD enzymes catalyze the hydroxylation of RNA polymerase subunits and myogenin. The EGLN1 protein functions as a cellular oxygen sensor. Under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event which targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in the EGLN1 gene are linked to erythrocytosis familial type 3 (ECYT3).

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

PAT21E9AT

Vial size

100 μg, 5 μg, 20 μg

Storage

Store at 4°C for short term and at -20°C for long term storage, Prevent freeze thaw cycles.