Antibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- FAB689A-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human GITR/TNFRSF18 APC-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human GITR in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) 4-1BB, recombinant mouse (rm) 4-1BB, rhCD27, rmCD27, rhCD30, rmCD30, rhCD40, rmCD40, rhDR3, rhDR6, rhEDAR, rmEDAR, rhFas, rmFAS, rmGITR, rhHVEM, rhLymphotoxin R beta , rmLymphotoxin R beta , rhNGF R, rhOPG, rmOPG, rhRANK, rmRANK, rhTAJ, rhTNF RI, rmTNF RI, rhTNF RII, or rmTNF RII.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Antigen sequence
Q9Y5U5
- Isotype
- IgG
- Antibody clone number
- 110416
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references CD4+CD25+ regulatory T-cell frequency in HER-2/neu (HER)-positive and HER-negative advanced-stage breast cancer patients.
Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.
Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma.
Perez SA, Karamouzis MV, Skarlos DV, Ardavanis A, Sotiriadou NN, Iliopoulou EG, Salagianni ML, Orphanos G, Baxevanis CN, Rigatos G, Papamichail M
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 May 1;13(9):2714-21
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 May 1;13(9):2714-21
Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.
Tuyaerts S, Van Meirvenne S, Bonehill A, Heirman C, Corthals J, Waldmann H, Breckpot K, Thielemans K, Aerts JL
Journal of leukocyte biology 2007 Jul;82(1):93-105
Journal of leukocyte biology 2007 Jul;82(1):93-105
Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma.
Yang XH, Yamagiwa S, Ichida T, Matsuda Y, Sugahara S, Watanabe H, Sato Y, Abo T, Horwitz DA, Aoyagi Y
Journal of hepatology 2006 Aug;45(2):254-62
Journal of hepatology 2006 Aug;45(2):254-62
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of GITR/TNFRSF18 in Human Blood CD4+ Lymphocytes by Flow Cytometry. Human peripheral blood CD4+ lymphocytes treated with PHA for 5 days were stained with Mouse Anti-Human GITR/TNFRSF18 APC-conjugated Monoclonal Antibody (Catalog # FAB689A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.