NB100-63601R

antibody from Novus Biologicals

Targeting: LAG3 CD223

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

NB100-63601R

Provider

Novus Biologicals

Product name

Rat Monoclonal LAG-3 Antibody

Antibody type

Monoclonal

Description

Protein G purified. NB100-63601 recognizes murine lymphocyte activation gene-3 (LAG-3), a 70kD activation-induced cell surface molecule that is also referred to as CD223. Murine CD223 is expressed on activated CD4 positive and CD8 positive alpha/beta T lymphocytes and a subset of natural killer (NK) cells. CD223 binds to MHC class II molecules with high affinity and is reported to negatively regulate T cell homeostasis and T cell expansion. Clone C9B7W recognizes an epitope within the D2 domain of CD223. The antibody is reported to block the in vitro function of murine LAG-3 but studies suggest that the antibody does not block binding of LAG-3 to MHC class II (1). 1. Workman, C.J. et al. (2002) Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3). Eur J Immunol. 32 (8): 2255-63

Reactivity

Mouse

Host

Rat

Conjugate

Yellow dye

Isotype

IgG

Vial size

0.125 ml

Storage

Store at 4C in the dark.