Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- ELISA [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- AF1729 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Sheep Polyclonal TREM2 Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects mouse TREM2 in direct ELISAs and Western blots. In direct ELISAs, less than 30% cross-reactivity with recombinant human TREM2 is observed.
- Reactivity
- Mouse
- Host
- Sheep
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice.
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
MicroRNA-101a regulates microglial morphology and inflammation.
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice.
Intracellular trafficking of TREM2 is regulated by presenilin 1.
Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
Differential modulation of TREM2 protein during postnatal brain development in mice.
In situ dividing and phagocytosing retinal microglia express nestin, vimentin, and NG2 in vivo.
Stephen TL, Cacciottolo M, Balu D, Morgan TE, LaDu MJ, Finch CE, Pike CJ
Acta neuropathologica communications 2019 May 21;7(1):82
Acta neuropathologica communications 2019 May 21;7(1):82
Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models.
Lee CYD, Daggett A, Gu X, Jiang LL, Langfelder P, Li X, Wang N, Zhao Y, Park CS, Cooper Y, Ferando I, Mody I, Coppola G, Xu H, Yang XW
Neuron 2018 Mar 7;97(5):1032-1048.e5
Neuron 2018 Mar 7;97(5):1032-1048.e5
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function.
Zhao Y, Wu X, Li X, Jiang LL, Gui X, Liu Y, Sun Y, Zhu B, Piña-Crespo JC, Zhang M, Zhang N, Chen X, Bu G, An Z, Huang TY, Xu H
Neuron 2018 Mar 7;97(5):1023-1031.e7
Neuron 2018 Mar 7;97(5):1023-1031.e7
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Cheng-Hathaway PJ, Reed-Geaghan EG, Jay TR, Casali BT, Bemiller SM, Puntambekar SS, von Saucken VE, Williams RY, Karlo JC, Moutinho M, Xu G, Ransohoff RM, Lamb BT, Landreth GE
Molecular neurodegeneration 2018 Jun 1;13(1):29
Molecular neurodegeneration 2018 Jun 1;13(1):29
Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury.
Castranio EL, Mounier A, Wolfe CM, Nam KN, Fitz NF, Letronne F, Schug J, Koldamova R, Lefterov I
Neurobiology of disease 2017 Sep;105:1-14
Neurobiology of disease 2017 Sep;105:1-14
MicroRNA-101a regulates microglial morphology and inflammation.
Saika R, Sakuma H, Noto D, Yamaguchi S, Yamamura T, Miyake S
Journal of neuroinflammation 2017 May 30;14(1):109
Journal of neuroinflammation 2017 May 30;14(1):109
Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice.
Nam KN, Mounier A, Wolfe CM, Fitz NF, Carter AY, Castranio EL, Kamboh HI, Reeves VL, Wang J, Han X, Schug J, Lefterov I, Koldamova R
Scientific reports 2017 Jun 27;7(1):4307
Scientific reports 2017 Jun 27;7(1):4307
Intracellular trafficking of TREM2 is regulated by presenilin 1.
Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H
Experimental & molecular medicine 2017 Dec 1;49(12):e405
Experimental & molecular medicine 2017 Dec 1;49(12):e405
Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
Zhang Z, Takeda-Uchimura Y, Foyez T, Ohtake-Niimi S, Narentuya, Akatsu H, Nishitsuji K, Michikawa M, Wyss-Coray T, Kadomatsu K, Uchimura K
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 4;114(14):E2947-E2954
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 4;114(14):E2947-E2954
Differential modulation of TREM2 protein during postnatal brain development in mice.
Chertoff M, Shrivastava K, Gonzalez B, Acarin L, Giménez-Llort L
PloS one 2013;8(8):e72083
PloS one 2013;8(8):e72083
In situ dividing and phagocytosing retinal microglia express nestin, vimentin, and NG2 in vivo.
Wohl SG, Schmeer CW, Friese T, Witte OW, Isenmann S
PloS one 2011;6(8):e22408
PloS one 2011;6(8):e22408
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Mouse TREM2 ELISA Standard Curve. Mouse TREM2 ELISA Standard Curve.
