MAB17291

antibody from R&D Systems

Targeting: TREM2 TREM-2, Trem2a, Trem2b, Trem2c

Flow cytometry (Recommended by provider)

Antibody Data

Product number

MAB17291

Provider

R&D Systems

Product name

Anti-Human/Mouse TREM-2 Monoclonal Antibody (Clone 237920)

Antibody type

Monoclonal

Antigen

Mouse myeloma cell line NS0-derived recombinant mouse TREM-2, extracellular domain

Description

Protein A or G purified from hybridoma culture supernatant

Reactivity

Human, Mouse

Host

Rat

Antigen sequence

Q99NH8


Isotype

IgG

Vial size

500 µg

References

Submitted references

Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis.

Garcia-Reitboeck P, Phillips A, Piers TM, Villegas-Llerena C, Butler M, Mallach A, Rodrigues C, Arber CE, Heslegrave A, Zetterberg H, Neumann H, Neame S, Houlden H, Hardy J, Pocock JM
Cell reports 2018 Aug 28;24(9):2300-2311

---

Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice.

Alves S, Churlaud G, Audrain M, Michaelsen-Preusse K, Fol R, Souchet B, Braudeau J, Korte M, Klatzmann D, Cartier N
Brain : a journal of neurology 2017 Mar 1;140(3):826-842

---

A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells.

Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T
The Journal of biological chemistry 2017 Jun 23;292(25):10651-10663

---

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.

Wu K, Byers DE, Jin X, Agapov E, Alexander-Brett J, Patel AC, Cella M, Gilfilan S, Colonna M, Kober DL, Brett TJ, Holtzman MJ
The Journal of experimental medicine 2015 May 4;212(5):681-97

---

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.

Kawabori M, Kacimi R, Kauppinen T, Calosing C, Kim JY, Hsieh CL, Nakamura MC, Yenari MA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Feb 25;35(8):3384-96

---

Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.

Savage JC, Jay T, Goduni E, Quigley C, Mariani MM, Malm T, Ransohoff RM, Lamb BT, Landreth GE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Apr 22;35(16):6532-43