MAB1828

antibody from R&D Systems

Targeting: TREM2 TREM-2, Trem2a, Trem2b, Trem2c

Western blot (Data presented on provider website)

Antibody Data

Product number

MAB1828

Provider

R&D Systems

Product name

Human TREM2 Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human TREM2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human TREM1, recombinant mouse (rm) TREM2b, or rmTREM3 is observed.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

Q9NZC2


Isotype

IgG

Antibody clone number

263602

Vial size

100 ug

Concentration

LYOPH

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

A data-driven approach links microglia to pathology and prognosis in amyotrophic lateral sclerosis.

Cooper-Knock J, Green C, Altschuler G, Wei W, Bury JJ, Heath PR, Wyles M, Gelsthorpe C, Highley JR, Lorente-Pons A, Beck T, Doyle K, Otero K, Traynor B, Kirby J, Shaw PJ, Hide W
Acta neuropathologica communications 2017 Mar 16;5(1):23

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TREM-2 binds to lipooligosaccharides of Neisseria gonorrhoeae and is expressed on reproductive tract epithelial cells.

Quan DN, Cooper MD, Potter JL, Roberts MH, Cheng H, Jarvis GA
Mucosal immunology 2008 May;1(3):229-38

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Pathological role of osteoclast costimulation in arthritis-induced bone loss.

Ochi S, Shinohara M, Sato K, Gober HJ, Koga T, Kodama T, Takai T, Miyasaka N, Takayanagi H
Proceedings of the National Academy of Sciences of the United States of America 2007 Jul 3;104(27):11394-9