AGTO-G052E

antibody from Creative Biolabs

Targeting: MSLN CAK1, MPF

No application information provided.

Antibody Data

Product number

AGTO-G052E

Provider

Creative Biolabs

Product name

Anti-MSLN immunotoxin RG7787 (Fab)-PE

Antibody type

Monoclonal

Description

This immunotoxin was achieved by conjugating/fusing the Anti-MSLN Fab to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells expressed the cells surface antigen MSLN. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating pancreatic cancer.

Reactivity

Human

Host

Mouse