BS6514

antibody from Bioworld Technology, Inc
Targeting: GRK3 ADRBK2, BARK2
Provider product page for BS6514
Western blot
Immunohistochemistry

Antibody data

Product number
BS6514 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GRK 3 /ADRBK2 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GRK 3.
Description
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of ÉÇ-adrenergic receptor kinase: GRK 2 (ÉÇARK, ÉÇARK1) and GRK 3 (ÉÇARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GRK3 protein structure - BS6514 shown in red.