CLTRN

This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]

Description

Collectrin, amino acid transport regulator

Tissue specificity

Tissue enriched (kidney)

Subcell location

Endoplasmic reticulum, Vesicles

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

X (15627318 - 15675012)

Ensembl ID

ENSG00000147003  (ver. 103.38)

Orthologs

-

UniProt

Q9HBJ8

neXtProt

NX_Q9HBJ8

Human splice variants

Protein structure