CABT-BL7171

antibody from Creative Diagnostics

Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL7171

Provider

Creative Diagnostics

Product name

Anti-CD274 Monoclonal antibody, clone NJI2 [APC]

Antibody type

Monoclonal

Description

Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member. To date, one specific receptor has been identified that can be ligated by PD-L1. This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation. Thus, PD-L1 might play an important role in tumor immune evasion.

Reactivity

Human

Host

Mouse

Isotype

IgG