345037

antibody from BioLegend

Targeting: HAVCR2 CD366, FLJ14428, Tim-3, TIM3, TIMD3

Flow cytometry (Data presented on provider website)

Blocking/Neutralizing (Recommended by provider)

Other assay (Recommended by provider)

Antibody Data

Product number

345037

Provider

BioLegend

Proper citation

BioLegend Cat#345037, RRID:AB_2566088

Product name

GoInVivo™ Purified anti-human CD366 (Tim-3)

Antibody type

Monoclonal

Antigen

Human Tim-3 fusion protein

Description

CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.

Reactivity

Human

Host

Mouse

Antibody clone number

F38-2E2

Vial size

1 g

Storage

2°C-8°C

Handling

Ambient RT