CABT-BL7603

antibody from Creative Diagnostics

Targeting: HAVCR2 CD366, FLJ14428, Tim-3, TIM3, TIMD3

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL7603

Provider

Creative Diagnostics

Product name

Anti-HAVCR2 Monoclonal antibody, clone G49-3F3 [eFluor? 450]

Antibody type

Monoclonal

Description

HAVCR2 is a 281 A.A Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It consists of an IgV-like domain and a mucin-like domain in the extracellular region and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. HAVCR2 plays an important role in the regulation of macrophage activation and induction of autoimmune diseases. It down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of HAVCR2 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease.

Reactivity

Human

Host

Mouse

Isotype

IgG