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Flow cytometry
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Flow cytometry [1]
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- Product number
- 345009 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#345009, RRID:AB_11150398
- Product name
- Ultra-LEAF™ Purified anti-human Tim-3 [F38-2E2]
- Antibody type
- Monoclonal
- Antigen
- Human Tim-3 fusion protein
- Description
- Tim-3 is a transmembrane protein also known as T cell immunoglobulin and musin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C. This Ultra-LEAF™ solution contains no preservative; handle under aseptic conditions.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Th1-polarized human peripheral blood mononuclear cells were stained with CD4 FITC and Tim-3 (clone F38-2E2) PE (top) or mouse IgG1, κ PE (bottom).
- Conjugate
- Unconjugated
